翁祖銓檢視原始碼討論檢視歷史
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翁祖銓，男，福州大學生物科學與工程學院教授。
人物簡歷
1998年—2003年 福建醫科大學，醫學學士學位
2003年—2009年 日本國立大阪大學，醫學博士學位
2009年—2011年 日本獨立行政法人勞動安全衛生綜合研究所 研究員
2012年—2015年 美國FDA國家毒理研究中心訪問學者
研究方向
社會兼職
1) 日本獨立行政法人勞動安全衛生綜合研究所客座研究員；
2) 中國工業毒理學會委員；
3)中國營養學會公共營養分會委員；
4) 中國環境誘變劑學會生物標誌物專業委員會委員；
5) 福建省食品安全地方標準審評委員會委員；
6) 福建省醫養結合專家。
科研項目
1) 福建省重大科技項目，福建省財政廳，83020008，燒創傷大數據研究中心平台建設，在研，主持
2) 中國國家自然科學基金委員會，面上項目，81971837，基因編輯斑馬魚促進燒傷創面修復再生的小鼠實驗研究，在研，主持
3) 福建省重點項目，福建省財政廳，83020007，基於高分子材料與技術構建燒傷創面敷料，在研，主持
4) 重大橫向課題，00801821，VR在燒傷救治方面的應用研究，在研，主持
5) 福州市科技計劃項目，82318030，豬飼料污染物 - 玉米赤霉烯酮的檢測試劑盒的研發，在研，主持
6) 福建省衛生教育聯合攻關計劃項目，83017000，酪氨酸激酶抑制劑類抗癌藥的肝毒性分析及相關機理研究，在研，主持
7) 福州市科技計劃項目，82316038，茶葉提取物-兒茶素功能性食品產業化的關鍵， 2結題，主持
8) 閩江學者（特聘教授）基金，510246，科研啟動基金，結題，主持
學術成果
論文
1）Yuanzi Wu, Shuigen Wu, Shanyun Ma, Fen Yan, and Zuquan Weng（通訊），Cytocompatible Modification of Thermoresponsive Polymers on Living Cells for Membrane Proteomic Isolation and Analysis. Analytic chemistry. 2019 Mar 5;91(5):3187-3194.
2）Tingfang Gao, Yuhong Shi,| Ying Xue, Fen Yan, Da Huang, Yuanzi Wu*, Zuquan Weng*（通訊）. Polyphenol extract from superheated steam processed tea waste attenuates the oxidative damage in vivo and in vitro. J Food Biochem. 2019 Nov 6:e13096. doi: 10.1111/jfbc.13096.
3）Shuting Chen, Jie Wu, Qiang Tang, Chenlan Xu, Yan Huang, Da Huang, Fang Luo, Yuanzi Wu, Fen Yan, Zuquan Weng（通訊）, Shaoyun Wang. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin. Carbohydr Polym. 2020 Jan 15;228:115398. doi: 10.1016/j.carbpol.2019.115398. Epub 2019 Sep 30.
4）Zuquan Weng, Yuhong Shi, Megumi Suda, Yukie Yanagiba, Toshihiro Kawamoto, Tamie Nakajima, Rui-Sheng Wang, Inhalation Exposure to Low Levels of Ethyl tertiary Butyl Ether: Its Genetic Effects Were Significantly Modified by ALDH2 Activity. Environ Mol Mutagen. 2019 Mar;60(2):145-153.
5）Wang H, Chen J, Suda M, Yanagiba Y, Weng Z（通訊）, Wang RS. Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice. J Appl Toxicol. 2019 Feb;39(2):260-270. doi: 10.1002/jat.3715.
6）Lin J, Wang H, Yan F, Tang K, Zhu H, Weng Z（通訊）, Wang K. Effects of occupational exposure to noise and dust on blood pressure in Chinese industrial workers. Clin Exp Hypertens. 2018;40(3):257-261. doi: 10.1080/10641963.2017.1368534. Epub 2017 Oct 31.
7）Zhang Y, Wang L, Luo F, Qiu B, Guo L, Weng Z（通訊）, Lin Z, Chen G. An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification. Chem Commun (Camb). 2017 Mar 7;53(20):2910-2913. doi: 10.1039/c7cc00009j.
8）Weng Z, Suda M, Wan M, Zhang X, Guan D, Zhao P, Zheng Y, Miyagawa M, Wang RS. Significant association between decreased ALDH2 activity and increased sensitivity to genotoxic effects in workers occupationally exposed to styrene. Oncotarget. 2016 Jun 21;7(25):38224-38234. doi: 18632/oncotarget.9502.
9）Wang K, Wan M, Wang RS, Weng Z（通訊）. Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events. J Med Internet Res. 2016 Apr 1;18(4):e76. doi: 10.2196/jmir.4541.
10）Jiamin Chen, Yuanzi Wu, Fen Yan, Da Huang, andZuquan Weng（通訊）, A fluorescent biosensor based on catalytic activity of platinum nanoparticles for rapid detection of hypoxanthine in aquatic products. Food Chem. 2020 Apr 25;310:125922. doi: 10.1016/j.foodchem.2019.125922. Epub 2019 Dec 4.
11）Liping Lin, Chenlan Xu, Yuehan Zhang, Zuquan Weng（通訊）, Rui-Sheng Wang, ALDH2 deficiency significantly exacerbates tertiary butyl alcohol-induced toxicity in mice. J Appl Toxicol. 2020 Jul;40(7):979-990. doi: 10.1002/jat.3957. Epub 2020 Feb 14.
12）Xiaobin Liu, Danhua Zheng, Yi Zhong, Zhaofan Xia, Heng Luo, and Zuquan Weng（通訊）, Machine learning prediction of oral drug-induced liver injury (DILI) via multiple features and endpoints. Biomed Res Int. 2020 May 19;2020:4795140. doi: 10.1155/2020/4795140.
13）Weng Z, Wang K, Li H, Shi Q. A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications. Oncotarget. 2015 6(19):17031-8.
14）Weng Z, Luo Y, Yang X, Greenhaw J, Xie L, Mattes W, Mendrick D, Shi Q. Regorafenib at clinically relevant concentrations impairs mitochondrial functions causing necrosis but not apoptosis in primary rat hepatocytes. Toxicology 2015 327:10-21.
15）Weng Z, Ohtani K, Suda M, Yanagiba Y, Kawamoto T, Nakajima T, Wang RS. Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH2. Arch Toxicol. 2014 88(4): 1007-1021.
16）Weng Z, Zhou P, Salminen WF, Yang X, Harrill AH, Cao Z, Mattes WB, Mendrick DL, Shi Q Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria. Biochem Biophys Res Commun. 2014 443(3): 1097-1104.
17）Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Subchronic Exposure to Ethyl tertiary Butyl Ether Resulting in Genetic Damage in Aldh2 Knockout Mice. Toxicology. 2013 311(3):107-114.
18）Weng Z, Greenhaw J, Salminen WF, Shi Q. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. 2012 Toxicol Lett. 214(3):328-338.
19）Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Differential Genotoxic Effects of Subchronic Exposure to Ethyl Tertiary Butyl Ether in the Livers of Aldh2 Knockout and Wild-type Mice. Arch Toxicol. 2012 86(4):675-682.
20）Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS. Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocytes due to Ethyl Tertiary Butyl Ether Exposure. Ind Health. 2011 49(3):396-399.
21）Weng H, Weng Z（共同第一作者）, Lu Y, Nakayama K, Morimoto K. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Mutat Res. 2010 701:132-136.
22）Weng H, Weng Z（共同第一作者）, Lu Y, Nakayama K, Morimoto K. Effects of cigarette smoking, XRCC1 genetic polymorphisms, and age on basal DNA damage in human blood mononuclear cells. Mutat Res. 2009 679:59-64.
23）Weng Z, Lu Y, Weng H, Morimoto K. Effects of the XRCC1 gene-environment interactions on DNA damage in healthy Japanese workers. Environ Mol Mutagen. 2008 49:708-719.
獲獎情況
1) 2012年獲得日本第82屆衛生學會年度總會議最優秀論文獎；
2) 2015年11月被授予福建省「閩江學者」特聘教授稱號；
3) 2016年5月被評為2015-2016學年福州大學創新創業活動優秀指導教師；
4) 2017年4月獲得福州大學青年五四獎章；
5) 2018年8月第三屆全國大學生生命科學創新創業大賽指導教師一等獎；
6) 2019年度第二屆福州大學「福能獎教金」獲得者。[1]