郭紅超檢視原始碼討論檢視歷史

郭紅超

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人物說明----中國農業大學理學院化學系主任 國 籍 ---- 中國 職 業 ---- 教育科研工作者 畢業院校----中國農業大學 學位/學歷----博士 專業方向----應用化學

郭紅超，男，中國農業大學理學院應用化學系教授、博士生導師、化學系主任，二級教授。1997年於中國農業大學應用化學系獲理學學士學位，2002年獲該校理學博士學位。2002-2010年先後在中國科學院上海有機化學研究所、德國馬普煤炭研究所、美國加州大學洛杉磯分校及伊利諾伊大學厄本那-香檳分校從事研究工作，2010年回國任教於中國農業大學，2012年晉升教授。

研究方向聚焦金屬催化、有機小分子催化及有機膦催化不對稱環加成反應，涉及手性氮雜環丁烯、軸手性聯烯等生物活性雜環化合物合成及新農藥創製。在《J. Am. Chem. Soc.》《Angew. Chem. Int. Ed.》《ACS Catal.》等期刊發表論文180餘篇，參與編寫專著5部，主持國家自然科學基金項目。2021年、2022年連續入選愛思唯爾中國高被引學者和全球前10萬傑出科學家榜單。

目錄

1人物經歷 ▪教育經歷 ▪工作經歷 2研究方向 3發表論文

人物經歷

教育經歷

1993-1997 中國農業大學應用化學系, 理學學士

1997-2002 中國農業大學應用化學系, 理學博士

工作經歷

2002-2004 中國科學院上海有機化學研究所, 博士後

2004-2006 德國馬普所(Muelheim), Research Associate

2006-2008 美國加州大學洛杉磯分校, 博士後

2008-2009 美國伊利諾伊大學厄本那-香檳分校, Research Associate

2009-2010 美國加州大學洛杉磯分校, 訪問學者

2010-2011 中國農業大學理學院應用化學系，副教授

2012-至今 中國農業大學理學院應用化學系，教授

研究方向

1.研究金屬和有機小分子催化的環加成及環化反應，特別是基於1,3-偶極子的高效、高選擇性環加成反應，發展高效的選擇性合成方法，並利用手性金屬催化劑和手性有機小分子催化劑發展高效和高選擇性的不對稱合成新方法，研究這些方法在雜環分子及複雜生物活性分子合成中的應用。

2.合成具有重要生物活性的雜環化合物及天然產物，用於殺蟲劑、除草劑、殺菌劑及植物生長調節劑等的研究，開展新農藥創製工作。

3.研究農藥的創新合成工藝。

發表論文

1.Xing Gao, Miaoren Xia, Chunhao Yuan, Leijie Zhou, Wei Sun, Cheng Li, Bo Wu, Dongyu Zhu, Cheng Zhang, Bing Zheng, Dongqi Wang, Hongchao Guo,* 「Enantioselective Synthesis of Chiral Medium-Sized Cyclic Compounds via Tandem Cycloaddition/Cope Rearrangement Strategy」, ACS Catal. 2019, 9, 1645−1654.

2.Wangyu Shi, Leijie Zhou, Biming Mao, Qijun Wang, Chang Wang, Cheng Zhang, Xuefeng Li, Yumei Xiao,* and Hongchao Guo,* 「Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines」, J. Org. Chem. 2019, 84, 679−686.

3.Honglei Liu, Yan Lin, Yan Zhao, Miaoren Xiao, Leijie Zhou, Qijun Wang, Cheng Zhang, Dongqi Wang, Ohyun Kwon,* Hongchao Guo,* 「Phosphine-Promoted [4 + 3] Annulation of Allenoate with Aziridines for Synthesis of Tetrahydroazepines: Phosphine-Dependent [3 + 3] and [4 + 3] Pathways」, RSC Adv. 2019, 8, 1214−1221.

4.Hongchao Guo,* Yi Chiao Fan, Zhanhu Sun, Yang Wu, and Ohyun Kwon,* 「Phosphine Organocatalysis」, Chem. Rev. 2018, 118, 10049−10293.

5.Leijie Zhou, Chang Wang, Chunhao Yuan, Honglei Liu, Cheng Zhang, and Hongchao Guo,* 「Phosphine-Catalyzed [3+2] Annulation of 2-Hydroxy-1,4-Naphthaquinones and Allenoate: An Allene-Alkene [3+2] Annulation Mechanism Involving Consecutive γ-Addition–Aldol Reaction」, Org. Lett. 2018, 20, 6591−6595.

6.Feng Jiang, Xinping Feng, Rou Wang, Xing Gao, Hao Jia, Yumei Xiao, Cheng Zhang,* and Hongchao Guo,* 「Asymmetric [3+3] Annulation of Copper−Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3-c]pyrazoles」, Org. Lett. 2018, 20, 5278–5281.

7.Zhenzhen Gao, Chang Wang, LeijieZhou, Chunhao Yuan, Yumei Xiao, Hongchao Guo,* 「Phosphine-Catalyzed [8+2]-Annulation of Heptafulvenes with Allenoates and Its Asymmetric Variant: Construction of Bicyclo[5.3.0]decane Scaffold」, Org. Lett. 2018, 20, 4302–4305.

8.Hao Jia, Zhenyan Guo, Honglei Liu, Biming Mao, Xueyan Shi,* Hongchao Guo,* 「Tandem Nucleophilic Addition–Cycloaddition of Arynes with α-Iminoesters: Two Concurrent Pathways to Imidazolidines」, Chem. Commun. 2018, 54, 7050–7053.

9.Honglei Liu, Hao Jia, Wangyu Shi, Chang Wang, Cheng Zhang, Hongchao Guo,* 「Nickel (II)-Catalyzed [8+3] Cycloaddition of 2-Aryl-N-tosyl-aziridines with Tropone」, Org. Lett. 2018, 20, 3570–3573.

10.Zhenyan Guo, Hao Jia, Honglei Liu, Qijun Wang, Jiaxing Huang, Hongchao Guo,* 「A [4+3] Annulation Reaction of aza-o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1H-benzo[e][1,2,4]triazepines」, Org. Lett. 2018, 20, 2939–2943.

11.Chang Wang, Yan Li, Yang Wu, Qijun Wang, Wangyu Shi, Chunhao Yuan, Leijie Zhou, Yumei Xiao, Hongchao Guo,* 「Enantioselective Construction of Tetrahydroquinazoline Motifs via Palladium-Catalyzed [4+2] Cycloaddition of Vinyl Benzoxazinones with Sulfamate-Derived Cyclic Imines」, Org. Lett. 2018, 20, 2880–2883.

12.Chunhao Yuan, Yang Wu, Dongqi Wang, Zhenhua Zhang, Chang Wang, Leijie Zhou, Cheng Zhang, Baoan Song, Hongchao Guo,* 「Formal [5+3] Cycloaddition of Zwitterionic Allylpalladium Intermediates with Azomethine Imines for Construction of N,O-Containing Eight-Membered Heterocycles」, Adv. Synth. Catal. 2018, 360, 652–658.

13.Leijie Zhou, Chunhao Yuan, Yuan Zeng, Honglei Liu, Chang Wang, Xing Gao, Qijun Wang, Cheng Zhang, Hongchao Guo,* 「Phosphine-Catalyzed [5+1] Annulation of δ-Sulfonamido-Substituted Enones with N-Sulfonylimines: A Facile Synthesis of Tetrahydropyridines」, Chem. Sci. 2018, 9, 1831–1835.

14.Chang Wang, Zhenzhen Gao, Leijie Zhou, Qijun Wang, Yang Wu, Chunhao Yuan, Jianning Liao, Yumei Xiao, Hongchao Guo,* 「Multifunctional Chiral Phosphine-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclopentenones: Asymmetric Synthesis of 4-oxo-Hexahydropentalenes」, Chem. Commun. 2018, 54, 279–282.

15.Qijun Wang, Chang Wang, Wangyu Shi, Yumei Xiao,* Hongchao Guo,* 「Pd-Catalyzed Diastereoselective [3+2] Cycloaddition of Vinylcyclopropanes with Sulfamate-Derived Cyclic Imines」, Org. Biomol. Chem. 2018, 16, 4881–4887.

16.Yuan Zeng, Leijie Zhou, Xing Gao, Yang Wu, Qijun Wang, Zhenyan Guo, Jiaxing Huang,* Hongchao Guo*, 「Diastereodivergent Synthesis of Pyrazoline Derivatives through [3+2] Cycloaddition of Baylis-Hillman Adducts and Nitrilimines」, J. Heterocyclic Chem. 2018, 55, 2781−2791.

17.Biming Mao, Wangyu Shi, Jianning Liao, Honglei Liu, Cheng Zhang, Hongchao Guo,* 「Phosphine-Catalyzed [4+2] Annulation of Allenoate with Sulfamate-Derived Cyclic Imines: A Reaction Mode Involving γ』-Carbon of α-Substituted Allenoate」, Org. Lett. 2017, 19, 6340–6343.

18.Yang Wu, Chunhao Yuan, Chang Wang, Biming Mao, Hao Jia, Xing Gao, Jianning Liao, Feng Jiang, Leijie Zhou, Qijun Wang, Hongchao Guo,* 「Palladium-Catalyzed [5+2] Cycloaddition of Vinyloxiranes with Sulfamate-Derived Cyclic Imines to Construct 1,3-Oxazepine Heterocycles」, Org. Lett. 2017, 19, 6268–6271.

19.Hao Jia, Honglei Liu, Zhenyan Guo, Jiaxing Huang, Hongchao Guo,* 「Tandem [3+2] Cycloaddition/1,4-Addition Reaction of Azomethine Ylides and aza-ortho-Quinone Methides for Asymmetric Synthesis of Imidazolidines」, Org. Lett. 2017, 19, 5236−5239.

20.Honglei Liu, Hao Jia, Bo Wang, Yumei Xiao, Hongchao Guo,* 「Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates」, Org. Lett. 2017, 19, 4714−4717.

21.Leijie Zhou, Chunhao Yuan, Cheng Zhang, Lei Zhang, Zhenzhen Gao, Chang Wang, Honglei Liu, Yang Wu, Hongchao Guo,* 「Enantioselective Synthesis of Quinazoline-Based Heterocycles through Phosphine-Catalyzed Asymmetric [3+3] Annulation of Morita−Baylis−Hillman Carbonates with Azomethine Imines」, Adv. Synth. Catal. 2017, 359, 2316–2321.

22.Wenjun Yang, Wei Sun, Cheng Zhang, Qijun Wang, Zhenyan Guo, Biming Mao, Jianning Liao, Hongchao Guo,* 「Lewis-Base-Catalyzed Asymmetric [3+3] Annulation Reaction of Morita–Baylis–Hillman Carbonates: Enantioselective Synthesis of Spirocyclohexenes」, ACS Catal. 2017, 7, 3142–3146.

23.Chang Wang, Hao Jia, Cheng Zhang, Zhenzhen Gao, Leijie Zhou, Chuanhao Yuan, Yumei Xiao, Hongchao Guo,* 「Phosphine-Catalyzed Enantioselective [2+4] Cycloaddition to Synthesize Pyrrolidin-2-one Fused Dihydropyrans Using α-Substituted Allenoates as C2 Synthons」, J. Org. Chem. 2017, 82, 633–641.

24.Xing Gao, Zhen Li, Wenjun Yang, Yang Liu, Wufeng Chen, Cheng Zhang, Lufei Zheng,* Hongchao Guo,* 「Phosphine-Catalyzed [3+2] and [4+2] Annulation Reactions of Ynones with Barbiturate-derived Alkenes for Synthesis of Spirobarbiturates and Dihydropyranopyrimidinediones」, Org. Biomol. Chem. 2017, 15, 5298–5307.

25.Honglei Liu, Yan Zhao, Zhen Li, Hao Jia, Cheng Zhang, Yumei Xiao, Hongchao Guo,* 「Lewis Base-Catalyzed Diastereoselective [3+2] Cycloaddition Reaction of Nitrones with Electron-Deficient Alkenes: An Access to Isoxazolidine Derivatives」, RSC Adv. 2017, 7, 29515–29519.

26.Bo Wang, Honglei Liu, Qijun Wang, Chunhao Yuan, Hao Jia, Chunxiao Liu, Hongchao Guo,* 「Thermal [3+2] Cycloaddition of Phthalazinium Dicyanomethanide with Allenoates」, Tetrahedron 2017, 73, 5926–5931.

27.Chunhao Yuan, Leijie Zhou, Miaoren Xia, Zhanhu Sun, Dongqi Wang, Hongchao Guo,* 「Phosphine-Catalyzed Enantioselective [4+3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles」, Org. Lett. 2016, 18, 5644–5647.

28.Honglei Liu, Yang Liu, Chunhao Yuan, Guo-Peng Wang, Shou-Fei Zhu, Yang Wu, Bo Wang, Zhanhu Sun, Yumei Xiao, Qilin Zhou,* Hongchao Guo,* 「Enantioselective Synthesis of Spirobarbiturate-Cyclohexenes through Phosphine-Catalyzed Asymmetric [4+2] Annulation of Barbiturate-Derived Alkenes with Allenoates」, Org. Lett. 2016, 18, 1302−1305.

29.Wenjun Yang, Chunhao Yuan, Yang Liu, Biming Mao, Zhanhu Sun, Hongchao Guo,* 「[4+3] Cycloaddition of Phthalazinium Dicyanomethanides with Azoalkenes Formed in Situ: Synthesis of Triazepine Derivatives」, J. Org. Chem. 2016, 81, 7597−7603.

30.Yang Wu, Yang Liu, Wenjun Yang, Honglei Liu, Leijie Zhou, Zhanhu Sun, Hongchao Guo,* Chiral Phosphine-Catalyzed Enantioselective [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclic 1-Azadienes: Synthesis of Functionalized Cyclopentenes, Adv. Synth. Catal. 2016, 358, 3517–3521.

31.Yang Liu, Wenjun Yang, Yang Wu, Biming Mao, Xing Gao, Honglei Liu, Zhanhu Sun, Yumei Xiao, Hongchao Guo,* 「Asymmetric Construction of Highly Functionalized Spirobarbiturate-Cyclopentenes through Chiral Phosphine-Catalyzed [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Barbiturate-Derived Alkenes」, Adv. Synth. Catal. 2016, 358, 2867−2872.

32.Zhen Li, Hao Yu, Yang Liu, Leijie Zhou, Zhanhu Sun, Hongchao Guo,* 「Phosphane-Catalyzed [3+3] Annulation of C,N-Cyclic Azomethine Imines with Ynones: A Practical Method for Tricyclic Dinitrogen-Fused Heterocycles」, Adv. Synth. Catal. 2016, 358, 1880−1885.

33.Chang Wang, Zhenzhen Gao, Leijie Zhou, Chunhao Yuan, Zhanhu Sun, Yumei Xiao,* Hongchao Guo, 「Phosphine-Catalyzed [2+4] Annulation of Allenoates with Thiazolone-Derived Alkenes: Synthesis of Functionalized 6,7-Dihydro-5H-pyrano[2,3-d]thiazoles」, Org. Lett. 2016, 18, 3418−3421.

34.Yumei Xiao, Hongchao Guo,* Ohyun Kwon,* 「Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations: Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations」, Aldrichim. Acta 2016, 49, 3−13.

35.Lei Zhang, Honglei Liu, Guanyu Qiao, Zhanfeng Hou, Yang Liu, Yumei Xiao, Hongchao Guo,* 「Phosphine-Catalyzed Highly Enantioselective [3+3] Cycloaddition of Morita-Baylis-Hillman Carbonates with C,N-Cyclic Azomethine Imines」, J. Am. Chem. Soc. 2015, 137, 4316–4319. This article was featured in Chinese Journal of Organic Chemistry 2015, 35, 1380–1382.

36.Chunhao Yuan, Honglei Liu, Zhenzhen Gao, Leijie Zhou, Yalin Feng, Yumei Xiao, Hongchao Guo,* 「Cu(I)-Catalyzed Highly Enantioselective [3+3] Cycloaddition between Two Different 1,3-Dipoles, Phthalazinium Dicyanomethanides and Iminoester-Derived Azomethine Ylides」, Org. Lett. 2015, 17, 26−29.

37.Zhenzhen Gao, Chang Wang, Chunhao Yuan, Leijie Zhou, Yumei Xiao,* Hongchao Guo,* 「Phosphine-Catalyzed [4+1] Annulation of 2-Tosylaminochalcones with Allenoates: Synthesis of trans-2,3-Disubstitued Indolines」, Chem. Commun. 2015, 51, 12653−12656.

38.Honglei Liu, Chunhao Yuan, Yang Wu, Yumei Xiao, Hongchao Guo,* 「Sc(OTf)3-Catalyzed [3+3] Cycloaddition of Cyclopropane 1,1-Diesters with Phthalazinium Dicyanomethanides」, Org. Lett. 2015, 17, 4220−4223.

39.Honglei Liu, Yang Wu, Yan Zhao, Zhen Li, Lei Zhang, Wenjun Yang, Hui Jiang, Chengfeng Jing, Hao Yu, Bo Wang, Yumei Xiao, Hongchao Guo,* 「Metal-Catalyzed [6+3] Cycloaddition of Tropone with Azomethine Ylides: A Practical Access to Piperidine-Fused Bicyclic Heterocycles」, J. Am. Chem. Soc. 2014, 136, 2625–2629.

40.Zhen Li, Hao Yu, Honglei Liu, Lei Zhang, Hui Jiang, Bo Wang, Hongchao Guo,* 「Phosphine-Catalyzed [3+2] Cycloaddition Reactions of Azomethine Imines with Electron-Deficient Alkenes: A Facile Access to Dinitrogen-Fused Heterocycles」, Chem. Eur. J. 2014, 20, 1731–1736.

41.Zhilin Yang, Hao Yu, Lei Zhang, Hang Wei, Yumei Xiao, Lanzhen Chen, Hongchao Guo,* 「PPh3-Catalyzed Ring-Expansion Reactions of Sulfamate-Derived Cyclic Imines with Acetylenedicarboxylates」, Chem. Asian J. 2014, 9, 313–318.

42.Yumei Xiao, Zhanhu Sun, Hongchao Guo,* Ohyun Kwon,* 「Chiral Phosphines in Nucleophilic Organocatalysis」, Beilstein J. Org. Chem. 2014, 10, 2089–2121.

43.Hao Yu, Lei Zhang, Zhilin Yang, Zhen Li, Yan Zhao, Yumei Xiao, Hongchao Guo,* 「Phosphine-Catalyzed [3+2] Cycloaddition of Sulfamate-Derived Cyclic Imines with Allenoate: Synthesis of Sulfamate-Fused Dihydropyrroles」, J. Org. Chem. 2013, 78, 8427–8436.

44.Hongchao Guo,* Honglei Liu, Fu-Lin Zhu, Risong Na, Hui Jiang, Yang Wu, Lei Zhang,Zhen Li, Hao Yu, Bo Wang, Yumei Xiao, Xiang-Ping Hu,* Min Wang, 「Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines」, Angew. Chem. Int. Ed. 2013, 52, 12641–12645.

45.Chengfeng Jing, Risong Na, Honglei Liu, Lei Zhang, Jun Liu, Min Wang, Jiangchun Zhong,* Ohyun Kwon, Hongchao Guo*, 「Phosphine-Catalyzed [3+2] and [4+3] Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates」, Adv. Synth. Catal. 2012, 354, 1023–1034.

46.Hongchao Guo, Kuiling Ding,* 「Self-Supported Chiral Catalysts for Heterogeneous Asymmetric Catalysis」, Chimia 2011, 65, 932–938.

47.Risong Na, Chengfeng Jing, Qihai Xu, Hui Jiang, Xi Wu, Jiayan Shi, Jiangchun Zhong, Min Wang, Diego Benitez, Ekaterina Tkatchouk, William A. Goddard, III, Hongchao Guo,* Ohyun Kwon,* 「Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3+2], [3+3], [4+3], and [3+2+3] Pathways」, J. Am. Chem. Soc. 2011, 133, 13337–13348

48.Zhiyuan Li, Min Wang, Qinghua Bian, Bing Zheng, Jianyou Mao, Shuoning Li, Shangzhong Liu, Ming-an Wang, Jiangchun Zhong,* Hongchao Guo,* 「Highly Enantioselective Addition of Trimethylsilylacetylene to Aldehydes Catalyzed by a Zinc-Amino-Alcohol Complex」, Chem. Eur. J. 2011, 17, 5782–5786.

49.Hongchao Guo, Kuiling Ding, 「Indium Tribromide」, Encyclopedia of Reagents for Organic Synthesis, 2011.

50.Hongchao Guo, Kuiling Ding, 「Self-Supported Chiral Catalysts」, In Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications, First Edition. Michelangelo Gruttadauria, Franceso Giacalone, Eds., John Wiley & Sons, Inc. 2011, Chapter 5, p.257–290.