韓生成檢視原始碼討論檢視歷史
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韓生成，男，北京師範大學生命科學學院教授。
人物簡歷
1992年畢業於南開大學生物系微生物學專業，獲學士學位；1997年獲得中國農業大學(原北京農業大學)生物化學及分子生物學專業博士學位，期間主要從事玉米花粉肌動蛋白的純化和結構分析的研究；1997年7月-1999年6月在中國科學院微生物研究所做博士後，從事轉基因水稻抗矮縮病毒的研究；1999年7月-2000年12月在美國加州大學聖地亞哥分校生物科學分部作博士後，研究微管結合蛋白-TANGLED1對玉米葉片細胞分裂及葉片發育的調控；2001年1月-2005年6月在美國杜克大學生物系作博士後，從事植物細胞鈣信號的研究；2005年7月-2008年6月在美國弗吉尼亞大學生物系作博士後，從事煙草尼古丁代謝的轉錄調控的研究；2007年9月被聘為北京師範大學教授，擔任「985工程」科技創新平台團隊研究員。2008年7月回國工作。
研究內容
植物鈣信號發生分子機制：重點探索感受不同內外源因素引起胞質鈣離子和核內鈣離子增加的受體或離子通道並解析其作用機制，揭示植物鈣信號轉導新通路。
水稻穎果發育轉錄調控機制：重點探索水稻初級穎果和次級穎果之間表達差異的關鍵編碼基因或非編碼基因作用機制及生物學功能，揭示水稻初次級穎果發育差異的分子機制，為提高水稻產量及改善品質提供基因資源。
研究成果
Yang Han, Yinxing Wang, Yuanjun Zhai, Zhaohong Wen, Jin Liu, Chao Xi, Heping Zhao, Yingdian Wang and Shengcheng Han# (2022) OsOSCA1.1 Mediates Hyperosmolality and Salt Stress Sensing in Oryza sativa. Biology, 11(5): 678.
Doudou Wang, Feifei Huang, Pengcheng Yan, Yanli Nie, Lvli Chen, Jin Luo, Heping Zhao, Yingdian Wang and Shengcheng Han# (2022) Cytosolic and nucleosolic calcium-regulated molecular networks in response to long-term treatment with abscisic acid and methyl jasmonate in Arabidopsis thaliana. Genes 13: 524.
Hanmeng Wang, Zhilin Chu, Shu Chang, Shenghua Jia, Lu Pang, Chao Xi, Jin Liu, Heping Zhao, Yingdian Wang#, Shengcheng Han# (2022) Transcriptomic identification of long noncoding RNAs and their hormone-associated nearby coding genes involved in the differential development of caryopses localized on different branches in rice. Journal of Plant Physiology 271: 153663.
Yihao Li, Kun Liu, Ganlu Tong, Chao Xi, Jin Liu, Heping Zhao, Yingdian Wang, Dongtao Ren, Shengcheng Han# (2022) MPK3/MPK6-mediated ERF72 phosphorylation positively regulates resistance to Botrytis cinerea through directly and indirectly activating the transcription of camalexin-biosynthesis enzymes. Journal of Experimental Botany 73(1): 413-428.
Shenghua Jia, Shu Chang, Hanmeng Wang, Zhilin Chu, Chao Xi, Jin Liu, Heping Zhao, Shengcheng Han# & Yingdian Wang# (2021) Transcriptomic analysis reveals the contribution of auxin on the differentially developed caryopses on primary and secondary branches in rice. Journal of Plant Physiology 256: 153310.
Yuanjun Zhai, Zhaohong Wen, Yang Han, Wenqing Zhuo, Fang Wang, Chao Xi, Jin Liu, Ping Gao, Heping Zhao, Yingdian Wang, Youjun Wang#, Shengcheng Han# (2020) Heterogeneous expression of plasma-membrane-localised OsOSCA1.4 complements osmotic sensing based on hyperosmolality and salt stress in Arabidopsis osca1 mutant. Cell Calcium 91: 102261
Shu Chang, Yixing Chen, Shenghua Jia, Yihao Li, Kun Liu, Zhouhua Lin, Hanmeng Wang, Zhilin Chu, Jin Liu, Chao Xi, Heping Zhao, Shengcheng Han# and Yingdian Wang# (2020) Auxin apical dominance governed by the OsAsp1-OsTIF1 complex determines distinctive rice caryopses development on different branches. PLoS Genetics 16(10): e1009157
Jin Luo, Lvli Chen, Feifei Huang, Ping Gao, Heping Zhao, Yingdian Wang, Shengcheng Han# (2020) Intraorganellar calcium imaging in Arabidopsis seedling roots using the GCaMP variants GCaMP6m and R-CEPIA1er. Journal of Plant Physiology 246–247; 153127
Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L. Gill, Shengcheng Han# and Youjun Wang# (2020) Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells. Cells 9, 275; doi:10.3390/cells9020275
Kun Liu, Yihao Li, Xuena Chen, Lijuan Li, Kai Liu, Heping Zhao, Yingdian Wang# and Shengcheng Han# (2018) ERF72 interacts with ARF6 and BZR1 to regulate hypocotyl elongation in Arabidopsis. J Exp Bot. 69 (16): 3933-3947.
Huang F, Luo J, Ning T, Cao W, Jin X, Zhao H, Wang Y and Han S# (2017) Cytosolic and nucleosolic calcium signaling in response to osmotic and salt stresses are independent of each other in roots of Arabidopsis seedlings. Front. Plant Sci. 8:1648. doi: 10.3389/fpls.2017.01648
Li Y., Yuan F., Wen Z., Li Y., Wang F., Zhu T., Zhuo W., Jin X., Wang Y., Zhao H., Pei Z-M and Han S.# (2015) Genome-Wide Survey and Expression Analysis of the OSCA Gene Family in Rice. BMC Plant Biology 15:261 doi:10.1186/s12870-015-0653-8
Nie Y., Huang F., Dong S., Li L., Gao P., Zhao H., Wang Y., and Han S# (2014) Identification of inositol 1,4,5-trisphosphate-binding proteins by heparin-agarose affinity purification and LTQ ORBITRAP MS in Oryza sativa. Proteomics 14: 2335-2338.[1]