楊維才檢視原始碼討論檢視歷史

楊維才
原圖鏈接 圖片來源個人圖書館 研究員， 博士生導師
出生	1964年
國籍	中國
職業	教育科研工作者

楊維才，男，1964年出生，博士，研究員，中科院遺傳與發育所博士生導師。

人物簡介

1984年蘭州大學學士。1987年蘭州大學碩士。1994年荷蘭Wageningen大學博士。1996-年美國Cold Spring Harbor實驗室博士後，1996-2000年新加坡國立大學分子農業生物學院博士後。2000－2002年新加坡國立大學分子農業生物學院高級科學家。植物生殖和棉花生物技術實驗室主任。2001年中國科學院"百人計劃"入選者。

楊維才博士領導的創新研究組主要研究方向是植物雌配子體發育過程中細胞極性及其與運之間的關係，其目標是利用擬南芥為模式植物來探討基本發育生物學問題，並以此為模式研究農作物基因功能。

主要研究

植物雌配子體發育

植物生殖生物學是一門傳統學科，傳統的研究主要集中於對生殖過程的結構,形態和組織胚胎學描述，由於方法和技術方面的局限,對其分子及遺傳機理的研究進展非常緩慢。年來由於Gene/enhancer Trap等系統和激光共聚焦顯微技術的應用。植物生殖生物學的研究出現了一線生機。研究組研究的領域主要集中在植物雌配子體的發育方面,如孢原細胞和胚囊中卵細胞，中央細胞的命運決定機理等.通過對配子體突變體的遺傳分析和基因克隆，了解植物生殖過程中的基因調控及分子機理。而對一些基本的生物學現象，如細胞極性、細胞命運的確立及受精機理等進行更深入的研究，了解植物的生殖過程。

以擬南芥為模式研究水稻基因組功能

在過去20多年，擬南芥作為模式植物在植物分子生物學，遺傳學，植物病理學，次生代謝和發育生物學研究方面得到了非常廣泛的應用，其6-8周的生活周期，相對小的基因組，自交，易於遺傳轉化，非常適合大規模繁殖等特點，使其成為首選的模式植物。該研究組希望建立一套以擬南芥為基礎的，快速有效的實驗系統，來研究農作物如水稻的基因功能，為農業生產提供技術儲備。

論文文獻

1992年

Franssen, H. J., I. Vijn, W. C. Yang and T. Bisseling (1992).Developmental aspects of the Rhizobium-legume symbiosis. Monographs inSystematic Botany; 10 Years plant molecular biology. R. A. Schilperoort and L.Dure. 41: 89-107.

1993年

Deblank, C., P. Mylona, W. C. Yang, P. Katinakis, T. Bisselingand H. Franssen (1993). "CHARACTERIZATION OF THE SOYBEAN EARLY NODULINCDNA CLONE GMENOD55." PlantMolecular Biology 22(6): 1167-1171.

Franssen, H., W.-C. Yang, P. Katinakis and T. Bisseling (1993). Characterizationof GmENOD40, a gene expressed in soybean nodule primordia. Current Plant Science and Biotechnology in Agriculture; New horizons innitrogen fixation. R. Palacios, J. Mora and W. E. Newton. 17: 275-284.

Kardailsky, I., W.-C. Yang, T. Bisseling and N. Brewin (1993). Small cysteine-richnodulins in pea nodule development. CurrentPlant Science and Biotechnology in Agriculture; New horizons in nitrogenfixation. R. Palacios, J. Mora and W. E. Newton. 17: 354-354.

Kardailsky, I., W. C. Yang, A. Zalensky, A. Vankammen and T. Bisseling (1993)."THE PEA LATE NODULIN GENE PSNOD6 IS HOMOLOGOUS TO THE EARLY NODULIN GENESPSENOD3/14 AND IS EXPRESSED AFTER THE LEGHEMOGLOBIN GENES." Plant Molecular Biology 23(5): 1029-1037.

1994年

Yang, W. C., C. Deblank, I. Meskiene, H.Hirt, J. Bakker, A. Vankammen, H. Franssen and T. Bisseling (1994)."RHIZOBIUM NOD FACTORS REACTIVATE THE CELL-CYCLE DURING INFECTION ANDNODULE PRIMORDIUM FORMATION, BUT THE CYCLE IS ONLY COMPLETED IN PRIMORDIUMFORMATION." Plant Cell 6(10):1415-1426.

Matvienko, M., K. Vandesande, W. C. Yang, A. Vankammen, T. Bisselingand H. Franssen (1994). "COMPARISON OF SOYBEAN AND PEA ENOD40 CDNA CLONESREPRESENTING GENES EXPRESSED DURING BOTH EARLY AND LATE STAGES OF NODULEDEVELOPMENT."Plant MolecularBiology 26(1): 487-493.

Mylona, P., M. Moerman, W. C. Yang, T. Gloudemans, J.Vandekerckhove, A. Vankammen, T. Bisseling and H. J. Franssen (1994). "THEROOT EPIDERMIS-SPECIFIC PEA GENE RH2 IS HOMOLOGOUS TO A PATHOGENESIS-RELATEDGENE."Plant Molecular Biology 26(1):39-50.

Demaagd, R. A.,W. C. Yang, L. G. D. Roo, I. H. M. Mulders, H. P. Roest, H. P.Spaink, T. Bisseling and B. J. J. Lugtenberg (1994). "DOWN-REGULATION OFEXPRESSION OF THE RHIZOBIUM-LEGUMINOSARUM OUTER-MEMBRANE PROTEIN GENE ROPAOCCURS ABRUPTLY IN INTERZONE II-III OF PEA NODULES AND CAN BE UNCOUPLED FROMNIF GENE ACTIVATION." MolecularPlant-Microbe Interactions 7(2): 276-281.

1995年

Franssen, H., P. Mylona, K. Pawlowski, K.Vandesande, R. Heidstra, R. Geurts, A. Kozik, M. Matvienko, W. C. Yang, A. E. Hadri, F.Martinezabarca and T. Bisseling (1995). "PLANT GENES INVOLVED INROOT-NODULE DEVELOPMENT ON LEGUMES." PhilosophicalTransactions of the Royal Society of London Series B-Biological Sciences 350(1331):101-107.

Vijn, I., F. Martinezabarca, W. C. Yang, L. Dasneves, A. Vanbrussel,A. Vankammen and T. Bisseling (1995). "EARLY NODULIN GENE-EXPRESSIONDURING NOD FACTOR-INDUCED PROCESSES IN VICIA-SATIVA."Plant Journal 8(1): 111-119.

Vijn, I., W. C. Yang, N. Pallisgard, E. O. Jensen, A. Vankammen and T.Bisseling (1995). "VSENOD5, VSENOD12 AND VSENOD40 EXPRESSION DURINGRHIZOBIUM-INDUCED NODULE FORMATION ON VICIA-SATIVA ROOTS." Plant Molecular Biology 28(6):1111-1119.

Bisseling, T., H. Franssen, H. Hirt, M.Matvienko, K. Pawlowski, K. Van De Sande, R. Walden and W.-C. Yang (1995). "Reactivation of mitotic activity in rootcortical cells by rhizobium lipo-oligosaccharides." Journal of Cellular Biochemistry Supplement 0(19A): 129-129.

Brito, B., J. M. Palacios, J. Imperial, T.Ruizargueso, W. C. Yang, T.Bisseling, H. Schmitt, V. Kerl, T. Bauer, W. Kokotek and W. Lotz (1995)."TEMPORAL AND SPATIAL COEXPRESSION OF HYDROGENASE AND NITROGENASE GENESFROM RHIZOBIUM-LEGUMINOSARUM BV VICIAE IN PEA (PISUM-SATIVUM L)ROOT-NODULES." MolecularPlant-Microbe Interactions 8(2): 235-240.

1996年

Christiansen, H., A. C. Hansen, I. Vijn, N.Pallisgaard, K. Larsen, W. C. Yang,T. Bisseling, K. A. Marcker and E. O. Jensen (1996). "A novel type ofDNA-binding protein interacts with a conserved sequence in an early nodulinENOD12 promoter." Plant MolecularBiology 32(5): 809-821.

1997年

Heidstra, R., W. C. Yang, Y. Yalcin, S. Peck, A. M. Emons, A. vanKammen and T.Bisseling (1997). "Ethylene provides positional information on corticalcell division but is not involved in Nod factor-induced root hair tip growth inRhizobium-legume interaction." Development 124(9): 1781-1787.

1999年

Kumaran, M. K., D. Ye,W.-C. Yang, M. E. Griffith, A. M. Chaudhury and V. Sundaresan(1999). "Molecular cloning of ABNORMAL FLORAL ORGANS: A gene required forflower development in Arabidopsis." SexualPlant Reproduction 12(2): 118-122.

Parinov, S., M. Sevugan, D. Ye, W. C. Yang, M. Kumaran and V.Sundaresan (1999). "Analysis of flanking sequences from Dissociationinsertion lines: A database for reverse genetics in Arabidopsis." Plant Cell 11(12): 2263-2270.

Yang,W. C., D. Ye, J. Xu and V. Sundaresan (1999)."The SPOROCYTELESS gene of Arabidopsis is required for initiation ofsporogenesis and encodes a novel nuclear protein." Genes & Development 13(16): 2108-2117.

2000年

Yang,W. C. and V. Sundaresan (2000). "Genetics ofgametophyte biogenesis in Arabidopsis." Current Opinion in Plant Biology 3(1): 53-57.

2001年

Compaan, B., W. C. Yang, T. Bisseling and H. Franssen (2001). "ENOD40expression in the pericycle precedes cortical cell division in Rhizobium-legumeinteraction and the highly conserved internal region of the gene does notencode a peptide." Plant and Soil 230(1):1-8.

2003年

Wu, X. M., S. H. Lim and W. C. Yang (2003)."Characterization, expression and phylogenetic study of R2R3-MYB genes inorchid." Plant Molecular Biology 51(6):959-972.

Yang, S. L., L. F. Xiea, H. Z. Mao, C. S.Puah, W. C. Yang, L. X. Jiang, V.Sundaresan and D. Ye (2003). "TAPETUM DETERMINANT1 is required for cellspecialization in the Arabidopsis anther."Plant Cell 15(12): 2792-2804.

2005年

Jiang, L. X., S. L. Yang, L. F. Xie, C. S.Puah, X. Q. Zhang, W. C. Yang, V.Sundaresan and D. Ye (2005). "VANGUARD1 encodes a pectin methylesterasethat enhances pollen tube growth in the Arabidopsis style and transmittingtract." Plant Cell 17(2):584-596.

Li, X. B., X. P. Fan, X. L. Wang, L. Caiand W. C. Yang (2005). "Thecotton ACTIN1 gene is functionally expressed in fibers and participates infiber elongation." Plant Cell 17(3): 859-875.

Rotman, N., A. Durbarry, A. Wardle, W. C. Yang, A. Chaboud, J. E. Faure, F.Berger and D. Twell (2005). "A novel class of MYB factors controlssperm-cell formation in plants." CurrentBiology 15(3): 244-248.

Shi, D. Q., J. Liu, Y. H. Xiang, D. Ye, V.Sundaresan and W. C. Yang (2005)."SLOW WALKER1, essential for gametogenesis in Arabidopsis, encodes a WD40protein involved in 18S ribosomal RNA biogenesis." Plant Cell 17(8): 2340-2354.

Yang, S. L., L. X. Jiang, C. S. Puah, L. F.Xie, X. Q. Zhang, L. Q. Chen, W. C. Yangand D. Ye (2005). "Overexpression of TAPETUM DETERMINANT1 alters the cellfates in the Arabidopsis carpel and tapetum via genetic interaction with EXCESSMICROSPOROCYTES1/EXTRA SPOROGENOUS CELLS." Plant Physiology 139(1): 186-191.

Ye, D., W.-C. Yang, V. Sundaresan and J. Xu (2005). Control of sporocyte ormeiocyte formation in plants, Temasek Life Sciences Laboratory Limited.

2006年

Song, X.-F., C.-Y. Yang, J. Liu andW.-C. Yang (2006). "RPA, a classII ARFGAP protein, activates ARF1 and U5 and plays a role in root hairdevelopment in Arabidopsis." PlantPhysiology 141(3): 966-976.

Ding, Y. H., N. Y. Liu, Z. S. Tang, J. Liuand W. C. Yang (2006)."Arabidopsis GLUTAMINE-RICH PROTEIN23 is essential for early embryogenesisand encodes a novel nuclear PPR motif protein that interacts with RNApolymerase II subunit III." PlantCell 18(4): 815-830.

Chen, Y.-H., X.-M. Wu, H.-Q. Ling and W.-C. Yang (2006). "Transgenicexpression of DwMYB2 impairs iron transport from root to shoot in Arabidopsisthaliana."Cell Research 16(10):830-840.

2007年

Meng, Z.-H., A.-H. Liang andW.-C. Yang (2007). "Effects ofhygromycin on cotton cultures and its application in Agrobacterium-mediatedcotton transformation." In Vitro Cellular & DevelopmentalBiology-Plant 43(2): 111-118.

Chen, Y.-H., H.-J. Li, D.-Q. Shi, L. Yuan,J. Liu, R. Sreenivasan, R. Baskar, U. Grossniklaus and W.-C. Yang (2007). "The central cell plays a critical role inpollen tube guidance in Arabidopsis." PlantCell 19(11): 3563-3577.

Escobar-Restrepo, J.-M., N. Huck, S.Kessler, V. Gagliardini, J. Gheyselinck, W.-C.Yang and U. Grossniklaus (2007). "The FERONIA receptor-like kinasemediates male-female interactions during pollen tube reception." Science 317(5838): 656-660.

2008年

Wang, F., D.-Q. Shi, J. Liu and W.-C. Yang (2008). "Novel nuclearprotein ALC-INTERACTING PROTEIN1 is expressed in vascular and mesocarp cells inArabidopsis." Journal of Integrative Plant Biology 50(7): 918-927.

Liu, N.-Y., Z.-F. Zhang and W.-C. Yang (2008). Isolation ofembryo-specific mutants in Arabidopsis - Genetic and phenotypic analysis.Methods in Molecular Biology. M. F.Suarez and P. V. Bozhkov. 427: 101-109.

2009年

楊維才
原圖鏈接 圖片來源百度 中科院遺傳發育所所長楊維才講話

Liu, M., L. Yuan, N.-Y. Liu, D.-Q. Shi, J.Liu and W.-C. Yang (2009)."GAMETOPHYTIC FACTOR 1, Involved in Pre-mRNA Splicing, Is Essential forMegagametogenesis and Embryogenesis in Arabidopsis." Journal of Integrative Plant Biology 51(3): 261-271.

Ruan, M.-B., Y.-T. Zhao, Z.-H. Meng, X.-J.Wang and W.-C. Yang (2009). "ConservedmiRNA analysis in Gossypium hirsutum through small RNA sequencing."Genomics 94(4): 263-268.

Xiao-ping, F. A. N., F. A. N. Bo-hong, X.U. Zi-qin and Y. Wei-cai (2009)."Cloning and Construction of GhcelA1 Gene in Cotton Fiber."Cotton Science 21(3): 236-242.

Li, N., L. Yuan, N. Liu, D. Shi, X. Li, Z.Tang, J. Liu, V. Sundaresan and W.-C.Yang (2009). "SLOW WALKER2, a NOC1/MAK21 Homologue, Is Essential forCoordinated Cell Cycle Progression during Female Gametophyte Development inArabidopsis." Plant Physiology 151(3):1486-1497.

Ruan, M.-B., Y.-T. Zhao, Z.-H. Meng, X.-J.Wang andW.-C. Yang (2009). "ConservedmiRNA analysis in Gossypium hirsutum through small RNA sequencing." Genomics 94(4): 263-268.

2010年

Deng, Y., H. Dong, J. Mu, B. Ren, B. Zheng,Z. Ji, W.-C. Yang, Y. Liang and J.Zuo (2010). "Arabidopsis Histidine Kinase CKI1 Acts Upstream of HISTIDINEPHOSPHOTRANSFER PROTEINS to Regulate Female Gametophyte Development andVegetative Growth." Plant Cell22(4): 1232-1248.

Liu, M., D.-Q. Shi, L. Yuan, J. Liu and W.-C. Yang (2010). "SLOW WALKER3,Encoding a Putative DEAD-box RNA Helicase, is Essential for FemaleGametogenesis in Arabidopsis."Journal of Integrative Plant Biology 52(9): 817-828.

Li, H.-J., N.-Y. Liu, D.-Q. Shi, J. Liu andW.-C. Yang (2010). "YAO is anucleolar WD40-repeat protein critical for embryogenesis and gametogenesis inArabidopsis."Bmc Plant Biology 10.

Yang,W.-C., D.-Q. Shi and Y.-H. Chen (2010). FemaleGametophyte Development in Flowering Plants. Annual Review of Plant Biology, Vol 61. S. Merchant, W. R. Briggsand D. Ort. 61: 89-108.

2011年

Yang,W.-C. and J. Wan (2011). "Transgenic Crops: AnOption for Future Agriculture." Journalof Integrative Plant Biology 53(7): 510-511.

Li, H.-J., Y. Xue, D.-J. Jia, T. Wang,D.-Q. Shi, J. Liu, F. Cui, Q. Xie, D. Ye and W.-C. Yang (2011). "POD1 Regulates Pollen Tube Guidance inResponse to Micropylar Female Signaling and Acts in Early Embryo Patterning inArabidopsis."Plant Cell 23(9):3288-3302.

Liu, W., W. Kohlen, A. Lillo, R. Op denCamp, S. Ivanov, M. Hartog, E. Limpens, M. Jamil, C. Smaczniak, K. Kaufmann, W.-C. Yang, G. J. E. J. Hooiveld, T.Charnikhova, H. J. Bouwmeester, T. Bisseling and R. Geurts (2011)."Strigolactone Biosynthesis in Medicago truncatula and Rice Requires theSymbiotic GRAS-Type Transcription Factors NSP1 and NSP2." Plant Cell 23(10): 3853-3865.

Shi, D.-Q. and W.-C. Yang (2011). "Ovule development in Arabidopsis: progressand challenge." Current Opinion inPlant Biology 14(1): 74-80.

2012年

Li, H.-J. and W.-C. Yang (2012). "Emerging role of ER quality control inplant cell signal perception."Protein & Cell 3(1): 10-16.

Wang, S.-Q., D.-Q. Shi, Y.-P. Long, J. Liuand W.-C. Yang (2012)."GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essentialfor female gametogenesis and male competence in Arabidopsis." PloS one7(4): e33595-e33595.

Zhao, Y.-T., M. Wang, S.-X. Fu, W.-C. Yang, C.-K. Qi and X.-J. Wang(2012). "Small RNA Profiling in Two Brassica napus Cultivars IdentifiesMicroRNAs with Oil Production- and Development-Correlated Expression and NewSmall RNA Classes." PlantPhysiology 158(2): 813-823.

社會評價

楊維才——中國科學院遺傳與發育生物學研究所（簡稱「遺傳發育所」）所長。長期以來，他投身於植物生殖發育調控機理研究 ，在Nature等雜誌上發表論文65篇，主持的「被子植物有性生殖的分子機理研究」獲2013年度國家自然科學獎二等獎，是該領域具有重要國際影響的學者。在科學中國人（2015）年度人物評選中，楊維才因其突出貢獻當選為生命科學領域年度人物 。

2016年，他的團隊對雌雄配子識別分子機制的系列研究取得了具有重大國際影響的突破，分離了花粉管識別胚囊雌性吸引信號的受體蛋白複合體並揭示其激活的分子機制。該研究通過基因工程手段建立利用生殖關鍵基因打破生殖隔離的方法，為克服雜交育種中雜交不親和性提供了重要理論依據。