李傑婕檢視原始碼討論檢視歷史
|
李傑婕，女，北京師範大學生命科學學院教授。
人物簡歷
- 2002年9月至2006年7月於中國農業大學生物學院獲理學學士學位；
- 2006年9月至2011年5月於中國農業大學生物學院獲博士學位，專業：植物學，導師：袁明教授；
- 2011年5月至2015年12月於美國普渡大學生物學院Chris Staiger教授實驗室從事博士後研究工作；
- 2016年6月至2017年6月就職於北京師範大學生命科學學院，任副教授。
- 2017年6月至今就職於北京師範大學生命科學學院，任教授。
研究內容
課題組主要致力於植物發育與免疫應答的細胞信號網絡研究。植物通過活躍的細胞骨架重排保障植物完成發育進程或者適應環境變化。特別是在植物與微生物相互作用過程中，細胞骨架-質膜-細胞壁連續體作為生物互作的第一道屏障（或免疫防線），在宿主與菌相互作用界面形成過程中發揮至關重要作用，同時也是微生物（病原菌或共生菌）分泌的效應蛋白或毒力因子的重要靶標。本課題組通過遺傳學，分子生物學，細胞生物學以及生物化學等手段，闡述微絲骨架在植物先天免疫過程中的作用及其分子機制。主要內容包括研究植物先天免疫過程中微絲骨架的動態變化規律；研究調控微絲骨架動態的上游免疫信號網絡及靶蛋白；闡明先天免疫過程中微絲骨架動態變化的生理學意義。
研究成果
- 1. Li, J., and Staiger, C.J.*. 2017. Understanding cytoskeletal dynamics during the plant immune response. Annu. Rev. Phytopathol. 2018. 56, in press.
- 2. Li, J., Cao, L., and Staiger, C.J.*. 2017.Capping protein modulates actin remodeling in response to reactive oxygen species during plant innate immunity. Plant Physiol. 173:1125-1136.
- 3. Li, J., Henty-Ridilla, J.L., Staiger, B.H., Day, B., and Staiger, C.J.*. 2015. Capping protein integrates multiple MAMP signaling pathways to modulate actin dynamics during plant innate immunity. Nat. Commun. 6: 7206.
- 4. Li., J., Blanchoin, L., and Staiger, C.J.*. 2015. Signaling to actin stochastic dynamics. Annu. Rev. Plant Biol. 66: 415-440.
- 5. Li, J., Arieti, R., and Staiger, C.J.*. 2014. Actin filament dynamics and their role in plant cell expansion. in Plant Cell Wall Patterning and Cell Shape. Edited by Fukada, H., published by John Wiley & sons. 127-162.
- 6. Li, J., Henty-Ridilla, J.L., Huang, S., Wang, X., Blanchoin, L., and Staiger, C.J.*. 2012. Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis. Plant Cell 24: 3742-3754.
- 7. Li, J., Wang, X., Qin, T., Zhang, Y., Liu, X., Sun, J., Zhou, Y., Zhu, L., Zhang, Z., Yuan, M. and Mao, T.*. 2011. MDP25, a novel calcium regulatory protein, mediates hypocotyl cell elongation by destabilizing cortical microtubules in Arabidopsis. Plant Cell 23: 4411-4427.
- 8. Li, J., Staiger, B.H., Henty-Ridilla, J.L., Abu-Abied, M., Sadot, E., Blanchoin, L., and Staiger, C.J.*. 2014 The availability of filament ends modulates actin stochastic dynamics in live plant cells. Mol. Biol. Cell 25: 1263-1275.
- 9. Li, J., Pleskot, R., Henty-Ridilla, J.L., Blanchoin, L., Potocký,M. and Staiger, C.J.*. 2012. Arabidopsis capping protein senses cellular phosphatidic acid levels and transduces these into changes in actin cytoskeleton dynamics. Plant Signal. Behav. 7: 1-4.
- 10. Henty-Ridilla, J.L., Li, J., Blanchoin, L., and Staiger, C.J.*. 2013. Actin dynamics in the cortical array of plant cells. Curr. Opin. Plant Biol. 16: 678-687.
- 11. Pleskot, R., Li J., Žárský, V., Potocký, M., and Staiger, C.J.*. 2013. Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid. Trends Plant Sci. 18: 496-504.
- 12. Henty-Ridilla, J.L., Li, J., Day, B., and Staiger, C.J.*. 2014. ADF4 regulates actin dynamics during innate immune signaling. Plant Cell 26: 340-352.
- 13. Wang, C., Li, J. and Yuan, M*. 2007. Salt tolerance requires cortical microtubule reorganization in Arabidopsis. Plant & Cell Physiol. 48: 1534-1547.
- 14. Qin, T., Li, J., Yuan, M. and Mao, T.*. 2012. Characterization of the role of calcium in regulating the microtubule-destabilizing activity of MDP25. Plant Signal. Behav. 7: 708-710.
- 15. Qin T., Liu X.M., Li J., Sun J.B., Song L.N., and Mao T.L.*. 2014. MDP25 functions in pollen tube growth by severing actin filaments. Plant Cell 26: 325-339.
- 16. Henty-Ridilla, J.L., Shimono,M., Li, J., Chang, J.H., Day, B., and Staiger, C.J.*. 2013. The plant actin cytoskeleton responds to signals from microbe-associated molecular patterns. Plos Pathog. 9,e1003290.
- 17. Meng, Q., Du, J., Li, J., Lü, X., Yuan, M. and Mao, T*. 2010. Tobacco microtubule-associated protein, MAP65-1c, bundles and stabilizes microtubules. Plant Mol. Biol. 74: 537-547.
- 18. Liu, B., Jin, L., Zhu, L., Li, J., Huang, S. and Yuan, M*. 2009. Phosphorylation of microtubule-associated protein SB401 from Solanum berthaultii regulates its effect on microtubules. J. Int. Plant Biol. 51: 235-242.[1]