時松海
| 時松海 |
時松海，男，漢族，1974年出生於江蘇省東台市廣山鎮廣山村，博士，教授。
1991年考入清華大學生物科學與技術系;2001年畢業於美國紐約州立大學石溪分校，獲遺傳學博士學位。
現任清華大學生命科學學院院長[1]， 清華大學-IDG麥戈文腦科學研究院院長[2]。
目錄
基本信息
人物說明----清華大學生命科學學院院長
民 族 ---- 漢族
出生地點----江蘇省東台市廣山鎮廣山村
出生日期----1974年
國 籍 ---- 中國
職 業 ---- 教育科研管理工作者
畢業院校----清華大學、紐約州立大學
學位/學歷----博士研究生
人物經歷
1991年-1996年，在清華大學生物科學與技術系學習，獲學士學位。
1996年-2001年，在紐約州立大學石溪分校學習，美國冷泉港實驗室工作，獲遺傳學博士。
2001年-2006年，在美國加州大學舊金山分校、霍華德-休斯醫學研究所工作。
2006年-2019年，在美國紀念斯隆-凱特琳癌症中心，先後擔任助理研究員、副研究員、研究員。
2006年-2019年，在美國康奈爾醫學院工作，先後擔任助理教授、副教授、教授。
2019年-，任清華大學生命科學學院院長， 清華大學-IDG麥戈文腦科學研究院院長。
研究興趣
神經系統是如何發育組裝的，以及如何調控動物的行為和認知一直是神經科學的研究熱點和終極目標之一。我們運用神經生物學(如電生理和成像)、遺傳學、分子、細胞和發育生物學等方法研究哺乳動物大腦的組裝和運行機制，集中於活體神經幹細胞的調控、神經細胞的產生分化遷移、神經環路的精準組裝和運行、以及動物行為的神經基礎;同時致力於與神經發育和功能相關的重大疾病如小腦症和自閉症的致病機制研究。
主要成就
學術論文
1. Shao, W., Yang, J., He, M., Yu, X.-Y., Lee, C.H., Yang, Z., Joyner, A.L., Anderson, K. V., Zhang, J., Tsou, M.B., Shi, H., and Shi, S.-H. (2020) Centrosome anchoring regulates progenitor properties and cortical formation. Nature 580:106-112. (PMCID: PMC7138347)
2. Chui, A., Zhang, Q., Dai, Q., Shi, S.-H. (2020) Oxidative stress regulates progenitor behavior and cortical neurogenesis. Development 147 (5). (PMCID: PMC7075051)
3. Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.-H. (2019) Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron.104, 1-17. (PMID: 31371111)
4. Lv X., Ren, S.-Q., Zhang, X.-J., Shen Z., Ghosh, T., Xianyu, A., Gao, P., Li, Z., Lin, S., Yu, Y., Zhang, Q., Groszer, M., and Shi, S.-H. (2019) TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex. Nat. Commun. 10(1):3946. (PMCID: PMC6718393)
5. Sultan, K.T., Liu, W.A., Li, Z.-L., Shen, Z., Li, Z., Zhang X.-J., Dean, O., Ma, J., and Shi, S.-H. (2018) Progressive divisions of Mmultipotent neural progenitors generate late-born chandelier cells in the neocortex. Nat. Commun. 9: 4595. (PMCID: PMC6214958)
| 時松海 |
6. Liu, W.-A., Chen, S., Li, Z., Lee, C.,-H., Mirzaa, G., Dobyns, W.B., Ross, M.E., Zhang, J., and Shi, S.-H. (2018) PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Genes & Dev. 32: 763-780. (PMCID: PMC6049519)
7. Zhang, X.-J., Li, Z., Han, Z., Sultan, K.T., Huang, K., and Shi, S.-H. (2017) Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters. Nat. Commun. 8:16091. (PMCID: PMC5511369)
8. Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H. (2017) Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus. Nat. Neurosci. 20: 516-528 (PMCID: PMC5374008)
9. Qi, Y., Zhang, X.-J., Renier, N., Wu, Z., Atkin, T., Sun, Z., Ozair, M.Z., Tchieu, J., Zimmer, B., Fattahi, F., Ganat, Y., Azevedo, R., Zeltner, N., Brivanlou, A.H., Karayiorgou, M., Gogos, J., Tomishima, M., Tessier-Lavigne, M., Shi, S.-H., and Studer, L. (2017) Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells. Nat. Biotechnol. 35:154-163. (PMCID: PMC5516899)
10. Sultan, K.T., Han, Z., Zhang, X.-J., Xianyu, A., Li, Z., Huang, K., and Shi, S.-H. (2016) Clonally related GABAergic interneurons do not randomly disperse but frequently form local clusters in the forebrain. ( Co-first author) Neuron 92: 31-44. (PMCID: PMC5066572)
11. Tan, X., Liu, W.A., Zhang, X.-J., Shi, W., Ren, S.-Q., Li, Z., Brown, K.N., and Shi, S.-H. (2016) Vascular regulation of ventral telencephalic progenitors and neocortical interneuron production. Dev. Cell 36:624-638. (PMCID: PMC4806403)
12. He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H. (2015) Inside-out radial migration facilitates lineage-dependent microcircuit assembly in the neocortex. Neuron 86: 1159-1166. (PMCID: PMC4458701)
13. Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H. (2014) Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell 159:775-788. (PMCID: PMC4225456)
14. Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H. (2014) Cortical neurogenesis in the absence of centrioles. Nat. Neurosci. 17:1528-1535. (PMCID: PMC4213237)
15. Insolera, R., Shao, W., Airik, R., Hildebrandt, F., and Shi, S.-H. (2014) SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing neocortex. Neuron 83: 805-822. (PMCID: PMC4141904)
16. Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H. (2014) Lineage-dependent structural and functional organization of the hippocampus. Cell 157: 1552-1564. (PMCID: PMC4120073)
17. Chen, S., Chen, J., Shi, H., Wei, M., Castaneda-Castellanos, D.R., Pei, X., Kriegstein, A.R., Zhang M.-J., and Shi, S.-H. (2013) Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev. Cell 24: 26-40. (PMCID: PMC3375857)
18. Li, Y., Lu, H., Cheng, P.-l., Ge, S., Xu, H., Shi, S.-H., and Dan, Y. (2012) Clonally related visual cortical neurons show similar stimulus feature selectivity. Nature 486:118-21. (PMCID: PMC3375857)
19. Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H. (2012) Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly. Nature 486:113-7. (PMCID: PMC3599787)
20. Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H. (2011) Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science 334: 480-486. (PMCID: PMC3304494)
21. Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H. (2009) Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461: 947-955. (PMCID: PMC2764320)
22. Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex. Neuron 63: 189-202. (PMCID: PMC2736606)
23. Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H. (2009) Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature 458: 501-504. (PMCID: PMC2727717)
24. Huang, C.S.*, Shi, S.-H.*, Ule, J., Ruggiu, M., Barker, L.A., Darnell, R.B., Jan, Y.N., and Jan, L.Y. (2005). Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell 123:105-118 (* contributed equally). (PMID: 16213216)
25. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351. (PMCID: PMC516569)
26. Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345. (PMID: 15340157)
27. Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112:63-75. (PMID: 12526794)
28. Shi, S.-H., Hayashi, Y., Esteban, J.A., and Malinow, R. (2001). Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105:331-343. (PMID: 11348590)
29. Hayashi, Y. *, Shi, S.-H. *, Esteban, J.A., Piccini, A., Poncer, J.-C., and Malinow, R. (2000). Driving AMPA receptors into synapses by LTP or CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287:2262-2267 (* contributed equally). (PMID: 10731148)
30. Shi, S.-H., Hayashi, Y., Petralia, R.S., Zaman, S.H., Wenthold, R.J., Svoboda, K., and Malinow, R. (1999). Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284:1811-1816. (PMID: 10364548)
獲獎記錄
2001年，論文《AMPA受體動力學與神經元突觸的可塑性》獲美國《科學》雜誌和阿默舍姆生物科學公司聯合設立的"全球青年科學家獎"。
2016年，獲HHMI首屆早期學者獎。
2019年，獲北京市卓越青年科學家稱號[3]。