張寧（教授）檢視原始碼討論檢視歷史
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張寧，男，北京大學基礎醫學院教授。國家「萬人計劃」入選者、國家傑出青年科學基金獲得者、科技部中青年科技創新領軍人才、人事部百千萬人才、突出貢獻專家教育部新世紀優秀人才，美國李氏基金會傑出成就獎獲得者。
學術任職
北京大學第一醫院腫瘤轉化研究中心常務副主任；中國抗癌協會常務理事、副秘書長，中國抗癌協會期刊出版專業委員會主任委員，納米腫瘤學專業委員會前任主任委員；中國老年學和老年醫學學會轉化醫學分委會主任委員；《Cancer Biology & Medicine》常務副主編，《Medical Review》副主編。
研究領域
從事生物醫學研究，圍繞肝癌這一關鍵臨床難題，從分子遺傳學、細胞生物學、藥物篩選、納米技術等多個側面入手展開轉化應用研究，取得了一系列科研成果。張寧教授近五年在Cancer Cell、Gastroenterology、Nature Communications等國際期刊中發表SCI文章44篇，榮獲細胞出版社（Cell Press）2019中國年度論文。同時，張寧教授的研究工作獲得國家基金委、科技部等多項基金的支持。
學術成果
代表作
1. Lin Guo#, Xianfu Yi#, Lu Chen#, Ti Zhang#, Hua Guo, Ziye Chen, Jinghui Cheng, Qi Cao, Hengkang Liu, Chunyu Hou, Lisha Qi, Zhiyan Zhu, Yucun Liu, Ruirui Kong, Chong Zhang, Xiaohua Zhou, Zemin Zhang, Tianqiang Song, Ruidong Xue*, Ning Zhang*. Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma. Gastroenterology. 2021 Sep 2;
2. Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou*, Ning Zhang*, Ruimao Zheng* & Zhengwei Xie*. Prediction of drug efficacy from transcriptional profiles with deep learning. Nature Biotechnology. 2021 Jun 17 ;
3. Chunqing Wang#, Yongmei Li# , Shuai Yan#, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen*, Ning Zhang*. Interactome Analysis Reveals That lncRNA HULC Promotes Aerobic Glycolysis Through LDHA and PKM2. Nature Communications. 2020 Jun 22; 11(1):3162.
4. Ruidong Xue#, Lu Chen#, Chong Zhang#, Masashi Fujita#, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng Li, Jingmin Zhao, Tao Peng, Yinying Lu, Kiat Hon Tony Lim, Arnoud Boot, Atushi Ohno, Kazuaki Chayama, Zemin Zhang, Steve George Rozen, Bin Tean Teh, Xin Wei Wang, Hidewaki Nakagawa*, Mu-Sheng Zeng*, Fan Bai*, Ning Zhang*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.e8.
5. Ping Zhou#, Jiaqi Qin#, Ce Zhou, Guoyun Wan, Yuanyuan Liu, Mingming Zhang, Xiaoying Yang, Ning Zhang*, Yinsong Wang*. Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer. Biomaterials. 2019 Mar;195:86-99.
6. Yun Liu, Xinran Zhang, Baicai Yang, Hao Zhuang, Hua Guo, Wen Wei, Yuan Li, Ruibing Chen, Yongmei Li*, Ning Zhang*. Demethylation-induced overexpression of Shc3 drives c-Raf-independent activation of MEK/ERK in HCC. Cancer Research. 2018 May 1;78(9):2219-2232.
7. Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang*, Haifang Yin*. Fluorescent peptide highlights micronodules in murine hepatocellular carcinoma models and human in vitro. Hepatology. 2018 Oct;68(4):1391-1411.
8. Ruibing Chen#, Yun Liu#, Hao Zhuang#, Baicai Yang, Kaiwen Hei, Mingming Xiao, Chunyu Hou, Huajun Gao, Xinran Zhang, Chenxi Jia, Lingjun Li, Yongmei Li*, Ning Zhang*. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Research. 2017 Sep 29;45(17):9947-9959.
9. Yan Gao#, Xiaohui Ni#, Hua Guo#, Zhe Su#, Yi Ba#, zhongsheng Tong, Zhi Guo, Xin Yao, Xixi Chen, Jian Yin, Zhao Yan, Lin Guo, Ying Liu, Fan Bai*, X. Sunney Xie*, Ning Zhang*. Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells. Genome Research. 2017 Aug;27(8):1312-1322. [1]