周珠賢檢視原始碼討論檢視歷史
| 周珠賢 |
 |
2023年獲得國家自然科學獎
基本信息
人物說明----浙江大學化工學院副教授、博士生導師
國 籍 ---- 中國
職 業 ---- 教育科研工作者
畢業院校----美國懷俄明大學化工系
學位/學歷----博士
專業方向----納米生物材料，藥物靶向輸送，可控藥物釋放
任職院校----浙江大學化工學院
目錄
1個人經歷 2研究方向 3學術成果
個人經歷
2018年1月-至今，浙江大學化工學院，副教授
2015年3月-2017年12月，浙江大學化工學院，講師
2015年3月回國加入申有青課題組
2011-2015年，美國凱斯西儲大學生物醫學工程系，博士後，Zheng-Rong Lu
2006-2011年，美國懷俄明大學化工系，博士，Youqing Shen
2003-2006年，浙江大學高分子系，碩士，孫維林
1999-2003年，浙江大學高分子系，學士
研究方向
高分子納米載體用於腫瘤的早期檢測和高效治療
1.高分子納米載體的精準合成與修飾
構建結構精準可控、可重複性高、藥物釋放可調的樹狀大分子和高分子自組裝納米藥物輸送系統，提高高分子載體的成藥性。
2.高分子納米載體用於早期腫瘤精準定位與定性診斷 構建靶向於腫瘤微環境的造影劑輸送系統（核磁共振造影劑、熒光探針等），實現對微小腫瘤的早期檢測以及惡性程度判斷。
3. 高分子納米載體用於腫瘤的高效治療
構建靶向於腫瘤的高效納米藥物輸送系統，針對腫瘤的特異性，研製自適應性納米藥物提高輸送各步的效率：延長血液循環時間、提高腫瘤積蓄、提高腫瘤內滲透性、增加細胞內吞速率和實現高效藥物定點釋放 [1]。
學術成果
發表SCI收錄文章60餘篇，H因子24，第一或通訊作者論文30餘篇包括：Nat. Commun., Angew.Chem.Inter.Ed., Adv. Mater., Adv. Funct. Mater.,Biomaterials,Adv. Drug Deliv. Rev.等國際著名期刊，論文被引用2000餘次，ESI高引6篇,文章目錄:[link]Google Scholar[link];Researchgate[link];ResearchID[link]
近期論文
Kexin Liu, Jiajia Xiang, Guowei Wang, Hongxia Xu, Ying Piao, Xiangrui Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Linear-Dendritic Polymer-Platinum Complexes Forming Well-Defined Nanocapsules for Acid-Responsive Drug Delivery. ACS Applied Materials & Interfaces 2021, 13, 37, 44028–44040.
Xinhao Fang, Kai Gao, Jianxiang Huang, Kexin Liu, Linying Chen, Ying Piao, Xiangrui Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery. Journal of Materials Chemistry B 2021, DOI: 10.1039/D1TB01157J.
Bo Zhang, Hongwen Chen, Qiuhui Hu, Liming Jiang, Youqing Shen, Dan Zhao, Zhuxian Zhou*, CelluMOFs: Green, Facile, and Flexible Metal-Organic Frameworks for Versatile Applications Advanced Functional Materials 2021, 31:2105395.
Guowei Wang, Chao Zhang, Yifan Jiang, Yue Song, Jifan Chen, Yu Sun, Qunying Li, Zhuxian Zhou*, Youqing Shen*, Pintong Huang*, Ultrasonic Cavitation-Assisted and Acid-Activated Transcytosis of Liposomes for Universal Active Tumor Penetration. Advanced Functional Materials 2021, 31:2102786.
Hongwen Chen, Huaqiang Chen, Bo Zhang, Liming Jiang, Youqing Shen, Engang Fu, Dan Zhao, Zhuxian Zhou*, Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks. Chinese Chemical Letters 2021, 32:1988-1992.
Zhen Zhang, Nasha Qiu, Shuling Wu, Xin Liu, Zhuxian Zhou, Jianbin Tang, Yanpeng Liu, Ruhong Zhou, Youqing Shen*, Dose-Independent Transfection of Hydrophobized Polyplexes. Advanced Materials 2021, 33:2102219.
Shiqi Hu#, Haiping Jiang#, Jianqiang Zhu, Jinqiang Wang, Shunhao Wang, Jianbin Tang, Zhuxian Zhou*, Sijin Liu*, Youqing Shen*, Tumor-Specific Fluorescence Activation of Rhodamine Isothiocyanate Derivatives. Journal of Controlled release 2021, 330:842-850.
Doudou Hu, Wei Zhang, Jianbin Tang, Zhuxian Zhou, Xiangrui Liu, Youqing Shen. Improving safety of cancer immunotherapy via delivery technology. Biomaterials 2021, 265:120407.
Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen. Progress and perspective of microneedle system for anti-cancer drug delivery. Biomaterials 2021, 264:120410.
Guowei Wang, Bihan Wu, Qunying Li, Siqin Chen, Xiaoqin Jin, Yajing Liu, Zhuxian Zhou,*Youqing Shen,* Pintong Huang*. Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small 2020; 16:2004172. (2020 IF:11.459)
Shiqi Hu#, Chengyuan Dong#, Jinqiang Wang, Kexin Liu, Quan Zhou, Jiajia Xiang, Zhuxian Zhou*, Fusheng Liu*, Youqing Shen*. Assemblies of Indocyanine Green and Chemotherapeutic Drug to Cure Established Tumors by Synergistic Chemo-Photo Therapy. Journal of Controlled Release 2020;324:250-259. (2019 IF: 7.901)
Hailin Cong#, Kaiqi Wang#, Zhuha Zhou, Jiajia Yang, Ying Piao, Bing Yu, Youqing Shen, Zhuxian Zhou*. Tuning the Brightness and Photostability of Organic Dots for Multivalent Targeted Cancer Imaging and Surgery. ACS Nano 2020;14:5887-5900.[link] (2019 IF: 13.903)
Guowei Wang, Zhuxian Zhou*, Zhihao Zhao, Qunying Li, Yulian Wu, Sheng Yan, Youqing Shen*, Pintong Huang*. Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors. ACS Nano 2020;14:4890-4904.[link] (2019 IF: 13.903)
Guowei Wang#, Dingcheng Zhu#, Zhuxian Zhou*, Ying Piao, Jianbin Tang, Youqing Shen*. A Glutathione-Specific and Intracellularly Labile Polymeric Nanocarrier for Efficient and Safe Cancer Gene Delivery. ACS Applied Materials & Interfaces 2020;12:14825-14838.[link] (2019 IF: 8.456)
Chengyuan Dong#, Quan Zhou#, Jiajia Xiang*, Fusheng Liu*, Zhuxian Zhou*, Youqing Shen. Self-assembly of Oxidation-Responsive Polyethylene Glycol-Paclitaxel Prodrug for Cancer Chemotherapy. Journal of Controlled Release 2020;321:529-539.[link] (2019 IF: 7.901)
Jiafeng Wang, Xuefei Zhou, Huifang Wang, Qian Xiao, Kefeng Ding, Xue Dong, Shufeng Xu, Bo Shen, Jihong Sun, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu*, Youqing Shen Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials 2020, 255:120156.
Kaojin Wang, Kamran Amin, Zesheng An, Zhengxu Cai, Hong Chen, Hongzheng Chen, Yuping Dong, Xiao Feng, Weiqiang Fu, Jiabao Gu, Yanchun Han, Doudou Hu, Rongrong Hu, Die Huang, Fei Huang, Feihe Huang, Yuzhang Huang, Jian Jin, Xin Jin, Qianqian Li, Tengfei Li, Zhen Li, Zhibo Li, Jiangang Liu, Jing Liu, Shiyong Liu, Huisheng Peng, Anjun Qin, Xin Qing, Youqing Shen, Jianbing Shi, Xuemei Sun, Bin Tong, Bo Wang, Hu Wang, Lixiang Wang, Shu Wang, Zhixiang Wei, Tao Xie, Chunye Xu, Huaping Xu, Zhi-Kang Xu, Bai Yang, Yanlei Yu, Xuan Zeng, Xiaowei Zhan, Guangzhao Zhang, Jie Zhang, Ming Qiu Zhang, Xian-Zheng Zhang, Xiao Zhang, Yi Zhang, Yuanyuan Zhang, Changsheng Zhao, Weifeng Zhao, Yongfeng Zhou, Zhuxian Zhou, Jintao Zhu, Xinyuan Zhu, Ben Zhong Tang*. Advanced functional polymer materials. Materials Chemistry Frontiers 2020, 4:1803-1915.
Dan Tian#, Hongxia Xu#, Bing Xiao, Xiaoxuan Zhou, Xiangrui Liu, Zhuxian Zhou, Hirak Kumar Patra*, Nigel KH Slater, Jianbin Tang*, Youqing Shen. Single-Step Formulation of Levodopa-Based Nanotheranostics–Strategy for Ultra-Sensitive High Longitudinal Relaxivity MRI Guided Switchable Therapeutics. Biomaterials Science 2020;8:1615-1621.[link] (2019 IF: 5.251)
Bing Xiao#, Xiaoxuan Zhou#, Hongxia Xu, Wei Zhang, Xiaodan Xu, Fengjuan Tian, Yue Qian, Feidan Yu, Cailing Pu, Hongjie Hu, Zhuxian Zhou, Xiangrui Liu, Hirak K Patra, Nigel Slater, Jianbin Tang*, Jianqing Gao, Youqing Shen. On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it. Biomaterials Science 2020, 8: 5210-5218.
Zixie Li, Jianxiang Huang, Long Ye, Yichao Lv, Zhuxian Zhou, Youqing Shen, Yi He, Liming Jiang*. Encapsulation of Highly Volatile Fragrances in Y Zeolites for Sustained Release: Experimental and Theoretical Studies. ACS Omega 2020, 5:31925