周強（教授）檢視原始碼討論檢視歷史

周強 北京大學深圳研究生院

周強，男，北京大學深圳研究生院教授。

人物簡歷

• 2014-至今 教授，北京大學深圳研究生院化生學院
• 2009-2013 研究員，美國基因和技術公司
• 2004-2009 助理教授，美國西乃山醫學院
• 2003-2004 副專家，美國加州大學伯克利分校
• 2001-2003 博士後，美國加州大學伯克利分校
• 1998-2000 博士後，美國加州大學舊金山分校
• 1998 博士，美國紐約州立大學石溪分校，神經生物學
• 1993 碩士，美國匹茲堡大學，生理學
• 1990 學士，清華大學，生物化學

獎項及榮譽

• 1999-2000 國家健康研究院實習生身份(美國加州大學舊金山分校)
• 2001-2004 國家健康研究院國家研究服務獎
• 2006-2009 新學者獎(埃里森醫學基金會)
• 2013 美國生物精神病學會年會最佳展示獎
• 1994-至今 美國神經科學學會會員

研究興趣

資深的成品管線項目管理經驗，為主要成品管線項目的生物學主管，主要研究方向是神經退化性疾病和精神疾病，也負責這些領域的商業開發與合作。

學術成果

• 1. Zhou Q, Godwin DW, O』Malley DM and Adams PR. Visualization of calcium influx through channels that shape the burst and tonic modes of thalamic relay cells. J. Neurophysiol. 77: 2816-2825, 1997.
• 2. Godwin DW, Che D, O』Malley DM and Zhou Q. Photostimulation with caged neurotransmitters using fiber optic light guides. J. Neurosci. Meth. 73: 91-106, 1997.
• 3. Cox CL, Zhou Q and Sherman SM. Glutamate locally activates dendritic outputs of thalamic interneurons. Nature 394: 478-482, 1998.
• 4. Zhou Q, Petersen CCH and Nicoll RA. Effect of reduced vesicular filling on synaptic transmission. J. Physiology 525 (1):195-206, 2000.
• 5. Zhou Q, Xiao MY and Nicoll RA. Contribution of cytoskeleton to the internalization of AMPA receptors. Proc. Natl. Acad. USA. 98: 1261-1266, 2001.
• 6. Frerking M, Schmitz D, Zhou Q, Johansen J and Nicoll RA. Kainate receptors depress excitatory synaptic transmission at CA3CA1 synapses in the hippocampus via a direct presynaptic action. J. Neurosci. 21: 2958-2966, 2001.
• 7. Xiao MY, Zhou Q and Nicoll RA. Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41: 664-671, 2001.
• 8. El-Husseini AE, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA and Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108: 849-863, 2002.
• 9. Zhou Q, Tao HW and Poo M-m. Reversal and stabilization of synaptic modifications in a developing visual system. Science 300, 1953-1957, 2003.
• 10. O』Malley DM, Zhou Q and Gahtan E. Probing neural circuits in the Zebrafish: a suite of optical techniques. Methods 30: 49-63, 2003.
• 11. Zhou Q, Homma, K and Poo, M-m. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44:749-757, 2004.
• 12. González-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC, Gingrich JA. Hallucinogens recruit specific cortical 5-HT(2A) receptor–mediated signaling pathways to affect behavior. Neuron 53:439-52, 2007.
• 13. Wang X, Yang Y and Zhou Q. Independent expression of synaptic and morphological plasticity associated with long-term depression. J. Neurosci. 27:12419-29, 2007.
• 14. Yang Y, Wang X, Frerking M and Zhou Q. Spine expansion and stabilization associated with long-term potentiation. J. Neurosci. 28:5740-51, 2008.
• 15. Yang Y, Wang X, Frerking M and Zhou Q. Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation. Proc. Natl. Acad. USA. 105: 11388-11393, 2008.
• 16. Wang X, Bozdagi O, Nikitczuk J, Zhai Z, Q. Zhou* and Huntley GW*. Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately. Proc. Natl. Acad. USA. 105:19520-19525, 2008. * - co-corresponding author
• 17. Sebeo J, Bozdagi O, Dumitriu D, Ge Y, Zhou Q and Benson D. Requirement for protein synthesis at young synapses. J. Neurosci. 29: 9778-93, 2009.
• 18. Yang Y, Wang XB, Zhou Q. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications. Proc. Natl. Acad. USA. 107: 11999-2004, 2010.
• 19. Bozdagi O, Wang XB, Nikitczuk JS, Anderson TR, Bloss EB, Radice GL, Zhou Q, Benson DL, Huntley GW. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci. 30: 9984-9, 2010.
• 20. Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein DL, Takahashi N, Kajiwara Y, Yang M, Katz AM,Scattoni ML, Harris MJ, Saxena R, Silverman JL, Crawley JN, Zhou Q, Hof PR, Buxbaum JD. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 1(1):15, 2010.
• 21. Hanson J, Weber M, Meilandt W, Wu T, Luu T, Deng L, Shamloo M, Sheng M, Scearce-Levie K and Qiang Zhou. GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. Neuropsychopharmacology. 38(7):1221-33, 2013.
• 23. Hanson J, Deng L, Hackos D, Lo JS, Lauffer B, Steiner P and Zhou Q. HDAC2 cell-autonomously suppresses excitatory and enhances inhibitory synaptic functions in hippocampal neurons. J. Neurosci. 33:5924-9, 2013.
• 24. Hanson J, La H, Plise E, Chen Y-H, Ding X, Lowe D, Steiner P, Liu L, Scearce-Levie K and Zhou Q. SAHA enhances synaptic function and plasticity in vitro but lack of brain availability in vivo prevents impacts on cognition. Plos One. 8(7):e69964, 2013.
• 25. Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, Weimer RM, Kirkpatrick DS, Lewcock JW. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med. 210:2553-67, 2013.
• 26. Hanson JE, Meilandt WJ, Gogineni A, Reynen P, Herrington J, Weimer RM, Scearce-Levie K, Zhou Q. Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. J Neurosci.34(24):8277-88, 2014.
• 27. Hanson JE, Pare JF, Deng L, Smith Y, Zhou Q. Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease. Neurobiol Dis.74:254-62, 2015.