周建榮檢視原始碼討論檢視歷史
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周建榮，男，北京大學深圳研究生院研究員。
人物履歷
1994-2000 新加坡國立大學Loh Teck-Peng教授指導下獲得化學理學學位和碩士學位
2000-2005 麻省理工學院師從Gregory Fu教授獲得有機化學博士學位
2005-2008 耶魯大學及後來在伊州大學香檳分校John Hartwig教授實驗室接受博士後訓練
2008-2019 南洋理工大學擔任助理教授，高等研究科學家和新加坡國家研究基金會研究員 2019 北京大學深圳研究生院研究員
獲獎情況
- 2008 Singapore National Research Foundation fellowship
- 2011-14 Asian Core Program Lectureship Award, 2011 Malaysia, 2012 Taiwan, 2013 Japan, 2014 China
- 2012 Thieme Chemistry Journals Award for young professors at early stages of academic career
- 2013 GSK-EDB Green and Sustainable Manufacturing Award, Singapore
- 2015 SPMS Young Researcher Award, Nanyang Technological University
- 2017 GSK-EDB Green and Sustainable Manufacturing Award, Singapore
- 2019 Bayer Investigator Award 拜耳研究者獎
研究興趣
主要集中在後過渡金屬催化反應，研究重點是基元C-C鍵的不對稱構建以及手性藥物和有生物活性化合物的合成。最近的研究興趣還包括光照下的金屬催化，自由基參與的催化反應， 小環的不對稱催化合成，含氟和含氘藥物的不對稱合成。正在進行的研究項目包括: 1）不對稱Heck反應，2）不對稱烯醇芳基化反應，3）鈀催化烷基化反應，4）鎳催化的不對稱轉移氫化反應，5）銅催化的不對稱加成反應。 作為通訊作者，已在 J Am Chem Soc 和 Angew Chem 上發表了30篇通訊論文。h-index 38. Citation 4300 (Google Scholar. 2021.4)
研究結果
1. 開發了一種環烯的高手性選擇性Heck反應催化劑，一種手性雙膦單氧化物Xyl-SDP(O)。它具有優異的底物通用性、高活性和高立體選擇性的特點 。新催化劑已由Sigma-Aldrich商業化。
2. 常見的末端烯烴在Heck反應中很難實現高區域選擇性。我組開發了這種催化劑，首次實現這些烯烴的alpha位選擇性芳基化。為此發明的二茂鐵雙膦配體DNPF已由Sigma-Aldrich商業化。
3. 開發了對映選擇性烯醇芳基化反應，第一次在酯、酮和內酯alpha位上形成對鹼敏感的叔碳手性中心。我組由此獲得了一項合成消炎藥Naproxen的美國專利。我們還首次報道了alpha氟酮和烷基腈的不對稱芳基化反應。
4. 開發了鈀催化下烯烴和普通鹵代烷間的Heck型烷基化反應。 我組後來成功將該自由基烷基化反應用於多種貧電雜環和芳環化合物。
5. 不對稱氫化反應已應用於手性藥的大規模生產，但這些反應高度依賴非常昂貴且稀缺的稀有過渡金屬催化劑，如銠和銥。製藥工業迫切需要解決這個工藝的可持續性問題。我組已發明了一系列均相鎳催化的不對稱轉氫化反應，底物包括烯、酮亞胺、肼等。
6. 在銅催化的芳基硼不對稱加成反應中， 發現並證實首例金屬催化中1，4-插入基元反應模式。
學術成果
1. Copper-Catalyzed Asymmetric Arylation of N-Heteroaryl Aldimines: Elementary Step of a 1,4-Insertion.Chunlin Wu, Xurong Qin, Adhitya Mangala Putra Moeljadi, Hajime Hirao, Jianrong Steve Zhou* (HH contributed DFT calculation) Angew. Chem. Int. Ed. 2019, 58, 2705-2709.
2. Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates and a Phosphinamide via Nickel Catalysis. Xiaohu Zhao, Haiyan Xu, Xiaolei Huang and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2019, 58, 592-596. Highlighted by Mark Lautens et al. in Synfacts 2019, 15(03), 0258
3. Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Xiaolei Huang, William Ray Jun Jie Oh and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2018, 57, 7673-7677.
4. Palladium-Catalyzed para-Selective Alkylation of Electron-Deficient Arenes. Zhiwei Jiao, Li Hui Lim, Hajime Hirao and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2018, 57, 6294-6298.
5. Nickel-Catalyzed N-Alkylation of both Acylhydrazines and Arylamines with Alcohols and Enantioselective Examples. Peng Yang, Caili Zhang, Yu Ma, Caiyun Zhang, Aijie Li, Bo Tang* and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 14702-14706. Highlighted by Yamamoto et al. Synfacts 2018, 14(2), 164.
6. Asymmetric Intermolecular Heck reaction of Propargylic Acetates and Cycloalkenes to Access Fused Cyclobutenes. Zhiwei Jiao, Qi Shi, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 14567-14571. Highlighted by Lautens et al. Synfacts 2018, 14(1), 48.
7. Nickel-Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Access Indolines. Xurong Qin, Marcus Wen Yao Lee, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 12723-12726. Highlighted by Lautens et al. Synfacts 2017, 13(10), 1040.
8. Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles. Zhiwei Jiao, Kwok Wei Chee, Jianrong Steve Zhou* J. Am. Chem. Soc. 2016,138, 16240. One of most read JACS articles of the month. Highlighted by Yamamoto et al. Synfacts 2017, 13(3), 274.
9. Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones. Zhiwei Jiao, Jason Beiger, Yushu Jin, Shaozhong Ge, Jianrong Steve Zhou,* John F. Hartwig* J. Am. Chem. Soc. 2016, 138, 15980. One of most read JACS articles of the month. Highlighted by Lautens et al. Synfacts 2017, 13(2), 155.
10. Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide. Peng Yang, Li Hui Lim, Pratanphorn Chuanprasit, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed calculation) Angew. Chem. Int. Ed. 2016, 55, 12083.
11. Asymmetric Conjugate Addition of Organoboron Reagents to Common Enones Using Copper Catalysts. Chunlin Wu, Guizhou Yue, Christian Duc-Trieu Nielson, Kai Xu, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed DFT calculation) J. Am. Chem. Soc. 2016,138, 742. One of the most read JACS articles of the month. Highlighted by Lautens et al. Synfacts 2016, 12(4), 394 and Organic Chemistry Portal in 2016.
12. Palladium-Catalyzed Direct Cyclopropylation of Heterocycles. Xiaojin Wu, Chuanhu Lei, Guizhou Yue, Jianrong (Steve) Zhou* Angew. Chem. Int. Ed. 2015, 54, 9601. Highlighted in Synform 2015, 12, A175.
13. Palladium-Catalyzed Asymmetric Reductive Heck Reaction of Aryl Halides. Guizhou Yue, Kaining Lei, Hajime Hirao, Jianrong (Steve) Zhou* Angew. Chem. Int. Ed. 2015, 54, 6531. One of the most accessed papers of the month in Angew Chem.[1]