呂丹檢視原始碼討論檢視歷史
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呂丹，男，北京大學基礎醫學院研究員。博士生導師。
人物履歷
中國免疫學會青年工作委員會委員。2006年本科畢業於中國醫科大學臨床醫學專業（87K），2011年畢業於北京大學基礎醫學院免疫學系，獲得博士學位。先後在美國Oklahoma Medical Research Foundation 以及北京大學做博士後。2018年正式加入北京大學系統生物醫學研究所。
研究方向
抗病毒與抗腫瘤免疫。先後主持包括國自然「優青」「面上」在內的多項國家級課題項目，並以第一作者或通訊作者身份在 Nature Immunology （ 2020 ， 2015 ） , Advanced Materials （ 2022 ） , Nature communications （ 2021 ） ， EMBO reports （ 2021 ）， Nano Research (2020) 等雜誌發表文章，獲得三項國家授權發明專利。目前正深入研究腫瘤和病毒免疫逃逸的發生機制，開發新型抗病毒和抗腫瘤納米藥物。
學術成果
論著
(1) Sun Y#, Gong L#, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F*, Lu D*, Lin Z*. A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification. Adv Mater. 2022 Feb 28:e2109580.
(2) Dan Lu#, Liu Liang#, Sun Yizhe, Song Jia, Yin Qi, Zhang Guangze, Qi Fang, Hu Zixi, Yang Zeliang, Zhou Ze, Hu Ying, Zhang Lianhai, Ji Jiafu, Zhao Xuyang, Jin Yan, McNutt MA, Yin Yuxin. The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity . Nat Immunol. 2020 Mar;21(3):287-297. PMID: 31932812.
(3) Sun Y#, Lu D#&*, Yin Y, Song J, Liu Y, Hao W, Qi F, Zhang G, Zhang X, Liu L, Lin Z, Liang H, Zhao X, Jin Y, Yin Y*. PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. Nat Commun. 2021 Aug 26;12(1):5147.
(4) Song J#, Liu T#, Yin Y, Zhao W, Lin Z, Yin Y*, Lu D*, You F*. The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity . EMBO Rep . 2021 Feb 3;22(2):e51162.
(5) Sun Y#, Yin Y, Gong L, Liang Z, Zhu C, Ren C, Zheng N, Zhang Q, Liu H, Liu W, You F, Lu D*, Lin Z*. Manganese nanodepot augments host immune response against coronavirus . Nano Res. 2020 Dec 29:1-13.
(6) Zhu C#, Ma Q, Gong L, Di S, Gong J, Wang Y, Xiao S, Zhang L, Zhang Q, Fu JJ*, Lu D*, Lin Z*. Manganese-based multifunctional nanoplatform for dual-modal imaging and synergistic therapy of breast cancer . Acta Biomater. 2022 Jan 15:S1742-7061(22)00019-8.
(7) Lu D#, Song J#, Sun Y, Qi F, Liu L, Jin Y, McNutt MA, Yin Y*. Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders. J Autoimmun . 2018 Aug 9; pii: S0896-8411(18)30333-0.
(8) Lu D#, Liu L#, Ji X, Gao Y, Chen X, Liu Y, Liu Y, Zhao X, Li Y, Li Y, Jin Y, Zhang Y, McNutt MA, Yin Y*. The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol. 2015 Dec; 16(12):1263-73.
(9) Lu D#, Dong D#, Zhou Y, Lu M, Pang XW, Li Y, Tian XJ, Zhang Y*, Zhang J*. The tumor-suppressive function o f UNC5D and its repressed expression in renal cell carcinoma. Clin Cancer Res. 2013 Jun 1; 19(11):2883-92.
(10) Lu D#, Zhao W#, Dong D, Qian XP, Zhang Y, Tian XJ*, Zhang J*. Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma. Eur J Cancer. 2011 Sep; 47(13):2068-76.[1]