江龍光檢視原始碼討論檢視歷史
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江龍光，男，福州大學化學學院副教授。
人物簡歷
教育經歷
2005.09 - 2010.07：中國科學院福建物質結構研究所，博士/Fujian Institute of Material Structure, Chinese Academy of Sciences，Ph.D.
（導師/Supervisor：黃明東 研究員/Prof. Mingdong Huang）
2001.09 - 2005.07：貴州大學，學士/Guizhou University, Bachelor
2016.02 – ：福州大學化學學院/College of Chemistry, Fuzhou University
2018.10 - 2019.10：哈佛醫學院，訪問學者/Harvard Medical School，Visiting Scholar
（合作導師/Supervisor： Prof. Robert C. Flaumenhaft, MD, Ph.D. ）
2014.07 - 2014.10：奧胡斯大學，訪問學者/Aarhus University, Visiting Scholar
（合作導師/Supervisor： Prof. Peter A. Andreasen, Ph.D. ）
2010.07 - 2016.01：中國科學院福建物質結構研究所，助理研究員/Fujian Institute of Material Structure, Chinese Academy of Sciences，Research Associate
《生物化學》/《Biochemistry》
《製藥工程專業英語》/《Professional English for Pharmaceutical Engineering》
《綜合化學實驗》/《Comprehensive Chemical Experiments》
《製藥工程創新創業實踐》/《Pharmaceutical Engineering Innovation and Entrepreneurship Practice》
社會兼職
福建省生物工程學會，理事
科研項目
1.福建省科技創新重點項目（2021G02004），2022-2023，項目負責人
2.國家自然科學基金面上項目（82070142），2021-2024，項目負責人
3.企業橫向項目，2020-2023，項目負責人
4.國家重點研發計劃項目（2017YFE0103200），2018-2021，研究骨幹
5.福建省自然科學基金面上項目（2018J01729），2018-2021，項目負責人
6.國家自然科學基金青年項目（31400637），2015-2017，項目負責人
7.福建省自然科學基金青年創新項目（2012J05071），2012-2015，項目負責人
學術成果
論文
(*: Equal contributions; #: co-corresponding authors)
30. Zhou Y, Wu J, Xue G, Li J, Jiang L#, Huang M#. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys J. 2022 Aug 29:S0006-3495(22)00694-4.
29.Wang R, Yang M, Jiang L#, Huang M#. Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions. Pharmacol Res. 2022 Aug;182:106331.
28. Sun G, Sui Y, Zhou Y, Ya J, Yuan C, Jiang L#, Huang M#. Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat. J Virol. 2021;95(19):e0086121.
27. 王蕊，黃美娟，許燕艷，袁彩，黃明東#，江龍光#，Ang-Tie軸在血管和淋巴系統相關疾病中作用的研究進展，生物工程學報，2021，37(8): 2633-2644.
26. Ma H*, Li R*, Jiang L*, Qiao S, Chen XX, Wang A, Zhang G. Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro. Vet Res. 2021;52(1):97.
25 Sun G, Yang M, Jiang L#, Huang M#. Regulation of pro-σK activation: a key checkpoint in Bacillus subtilis sporulation. Environ Microbiol. 2021;23(5):2366-2373.
24 Jiang L, Yuan C, Huang M. A general strategy to inhibit serine protease by targeting its autolysis loop. FASEB J. 2021;35(2):e21259.
23. Yuan C, Guo Z, Yu S, Jiang L#, Huang M#. Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discov Today. 2021;26(4):1076-1085.
22. Huang M, Li L, Shen J, Wang Y, Wang R, Yuan C, Huang M#, Jiang L#. Plasma levels of the active form of suPAR are associated with COVID-19 severity. Crit Care. 2020;24(1):704.
21. Zhou Y, Chen D, Xue G, Yu S, Yuan C, Huang M#, Jiang L#, Improved therapeutic efficacy of quercetin-loaded polymeric nanoparticles on triple-negative breast cancer by inhibiting uPA, RSC Adv., 2020,10, 34517-34526.
20. G Xue, X Xie, Y Zhou, C Yuan, M Huang#, Jiang L#. Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases. Biosci Biotechnol Biochem. 2020;84(6):1153-1159.
19. Xie X, Guo N, Xue, Xie D, Yuan C, Harrison J, Li J, L. Jiang L#, Huang M#. Solution structure of SpolVB reveals mechanism of PDZ domain-regulated protease activity. Frontiers in Microbiology, 2019;10,1232.
18. Jiang J, Xie X, Li J, Persson E, Huang M. Crystal structure, epitope and functional impact of an antibody against a super-active FVIIa provide insights into allosteric mechanism. Research and Practice in Thrombosis & Haemostasis, 2019; 3(3);412-419.
17. Jiang L, Zhang X, Zhou Y, Chen Y, Luo Z, Li J, Yuan C, Huang M. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases. RSC Advances, 2018;8, 28189.
16. Jiang L, Oldenburg E, Kromann-Hansen T, Xu P, Jensen JK, Andreasen PA, Huang M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim Biophys Acta. 2018;1862(9):2017-2023.
15. Sun YG*, Li R*, Jiang L*, Qiao S, Zhi Y, Chen XX, Xie S, Wu J, Li X, Deng R, Zhang G. Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus. Int J Biol Macromol. 2018; 117:704-712.
14. Xie X, Xue G, Jiang L#, Huang M#. Ligand Induced Conformational Transitions of Tissue Factor Ω loop, Chinese J. Struct. Chem. 2018;37(6), 961-968.
13. Xu M, Chen Y, Xu P, Andreasen PA, Jiang L#, Li J#, Huang M#. Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217. FEBS Lett. 2018;592(15):2658-2667.
12. Xu M, Xu P, Zhou X, Andreasen PA, Jiang L#, Huang M#. Crystal structures of the serine protease domain of murine plasma kallikrein, Chinese J. Struct. Chem. 2017, 36(2), 961-968.
11. Xue G, Gong L, Yuan C, Xu M, Wang X, Jiang L#, Huang M. A structural mechanism of flavonoids in inhibiting serine proteases. Food Funct. 2017;8(7):2437-2443.
10. Ma H, Qiao S, Huang M, Jiang L#, Li R#, Zhang G#. Crystal Structure of a CD163 Scavenger Receptor Cysteine-rich Domain Produced in Pichia Pastoris, Chinese J. Struct. Chem. 2017, 36(9), 961-968.
9. Ma H*, Jiang L*, Qiao S, Zhi Y, Chen XX, Yang Y, Huang X, Huang M, Li R, Zhang GP. Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain (SRCR5) from Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection. J Virol. 2017;91(3): e01897-16.
8. Jiang L, Lin L, Li R, Yuan C, Xu M, Huang JH, Huang M. Dimer conformation of soluble PECAM-1, an endothelial marker. Int J Biochem Cell Biol. 2016;77 (Pt A):102-108.
7. Jiang L, Andersen LM, Andreasen PA, Chen L, Huang M. Insights into the serine protease mechanism based on structural observations of the conversion of a peptidyl serine protease inhibitor to a substrate. Biochim Biophys Acta-General subjects. 2016; 1860 (3):599-606.
6. Jiang L, Zhao B, Xu P, Sørensen HP, Jensen JK, Christensen A, Hosseini M, Nielsen NC, Jensen KJ, Andreasen PA, Huang M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int J Biochem Cell Biol. 2015; 62:88-92.
5. Jiang L, Botkjaer KA, Andersen LM, Yuan C, Andreasen PA, Huang M. Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem J. 2013 Jan 1; 449 (1): 161-6.
4. Jiang L*, Svane AS*, Sørensen HP, Jensen JK, Hosseini M, Chen Z, Weydert C, Nielsen JT, Christensen A, Yuan C, Jensen KJ, Nielsen NC, Malmendal A, Huang M, Andreasen PA. The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor. J Mol Biol. 2011;412(2), 235-50.
3. Jiang L, Yuan, C, Chen, H, Wang, Y, Zhao, B, Zhang, X, and Huang, M, Preparation and structure of a new coagulation factor XI catalytic domain for drug discovery. Chinese J. Struct. Chem. 2011;30 (7), 1021-59.
2. Jiang L, Zhao G, Bian C, Yuan C, Huang Z, Huang M. Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol. Chinese J. Struct. Chem. 2009; 28(2), pp. 253-259.
1. Jiang, L, Yu H, Yuan C, Wang J, Chen L, Edward J. Meehan, Huang Z, Huang M. The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator. Chinese J. Struct. Chem. 2009;28(11):1427-1432.
獲獎情況
2020年度「鴻耀獎教獎」；2021年「廈航獎教獎」[1]