王欢(研究员)查看源代码讨论查看历史
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王欢,女,北京大学基础医学院研究员。博士生导师。
人物履历
2018.7 ~ 至今北京大学基础医学院系统生物医学研究所副研究员
2014.9 ~ 2018.6 哈佛医学院,系统生物学系,博士后(导师:Peter K. Sorger)
2013.5 ~ 2014.9 科罗拉多大学波尔德分校,化学与生物工程系,博士后(导师:Kristi S. Anseth)
2006.9 ~ 2013.5 科罗拉多大学波尔德分校,分子,细胞与发育生物学系,博士(导师: Leslie A. Leinwand and Kristi S. Anseth)
2004.9 ~ 2005.6 香港中文大学, 生物系, 交换学生
2002.9 ~ 2006.7 浙江大学,生物技术系,学士
研究方向
包括抗肿瘤药物引起心脏毒性的机制及潜在靶点,多组学数据的整合分析,微环境理化因子的调控机制。
学术任职
目前担任中国病生理学会系统生物医学青年专委会委员。
学术成果
Representative publications (代表性论文):
1. Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Alison RE, Maliszewski L, Haigis MC, Sorger PK. Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Syst 8, 412-426.e7 (2019).
2. Wang H, Tibbitt MW, Langer SJ, Leinwand LA and Anseth KS. Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway. Proceedings of the National Academy of Sciences USA, 110 (48): 19336-19341 (2013).
3. Wang H, Leinwand LA and Anseth KS. Cardiac valve cells and their microenvironment—insights from in vitro studies, Nature Reviews Cardiology, 11(12):715-727 (2014).
4. Wang H, Leinwand LA and Anseth KS. Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation, The FASEB Journal, 28(10):4551-4562 (2014).
5. Wang H, Haeger SM, Kloxin AK, Leinwand LA and Anseth KS. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS ONE, 7(7):e39969 (2012).
6. Wang H, Sridhar B, Leinwand LA, Anseth KS. Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves. PLoS ONE, 8(7): e69667. [1]