付毅
人物履歷
2009年獲北京大學醫學部生理學博士學位。2009-2012年在澳大利亞Baker IDI Heart and Diabetes Institute從事博士後研究工作。
學習經歷
1999-2004 四川大學華西臨床醫學院 臨床醫學學士
2004-2009 北京大學醫學部基礎醫學院 生理學博士
工作經歷
2009-2012 澳大利亞Baker IDI Heart and Diabetes Institute 博士後 專業：血管藥理學
2012-至今 北京大學醫學部生理學與病理生理學系 專業：人體生理學
研究方向
學術任職
現任中國生理學會基質生物學專業委員會委員和青年工作委員會委員。
學術成果
論文
1. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021;31(7):773-790.
2. Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y*, Fu Y*. The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA. Am J Physiol Cell Physiol. 2019;317(4):C762-C775.
3. Ma B, Yao F, Xie N, Mao C, Liu F, Gong Z, Zhao G, Liu Z, Cai Z, Yu F, Dai R, Chen Z, Wang L, Xu Q*, Kong W*, Fu Y*. Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage. J Mol Cell Cardiol. 2018;121:69-80.
4. He L#, Fu Y#, Deng J, Shen Y, Wang Y, Yu F, Xie N, Chen Z, Hong T, Peng X, Li Q, Zhou J, Han J, Wang Y, Xi J, Kong W. Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol. 2018;38(7):1616-1631.
5. Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li Y, Xu Q, Wang X, Kong W. Shift of Macrophage Phenotype due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. Circ Res. 2016;119(2):261-76.
6. Gao C#, Fu Y#, Li Y, Zhang X, Zhang L, Yu F, Xu SS, Xu Q, Zhu Y, Guan Y, Wang X, Kong W. Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol. 2016;36(1):108-21.
7. Yang N, Yu F, Shao G, Fu Y*, Kong W*. The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy. Biochem Biophys Res Commun. 2016;479(4):728-735.
8. Liang Y#, Fu Y#, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015;126(7):905-14.
9. Fu Y*, Moore XL, Lee MK, Fernández-Rojo MA, Parat MO, Parton RG, Meikle PJ, Sviridov D, Chin-Dusting JP. Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arterioscler Thromb Vasc Biol. 2012;32(9):e117-25.
10. Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain. Circ Res. 2011;108(4):410-7.
發表特邀綜述4篇。
1. Ma Z, Mao C, Jia Y, Fu Y*, Kong W. Extracellular matrix dynamics in vascular remodeling. Am J Physiol Cell Physiol. 2020;319(3):C481-C499.
2. Fu Y, Wang X, Kong W. Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets. Br J Pharmacol. 2018;175(8):1173-1189.
3. Fu Y, Kong W. Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease. Curr Vasc Pharmacol. 2017;15(3):186-196.
4. Fu Y, Zhu Y. Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target. Curr Pharm Des. 2010;16(37):4074-9.[1]