譚煥然檢視原始碼討論檢視歷史
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譚煥然，女，北京大學基礎醫學院教授。
人物履歷
畢業於北京醫學院（北京大學醫學部）基礎醫學專業。多年來一直從事基因和分子生物學以及分子藥理學方面的研究工作。1991年作為訪問學者在著名的分子生物學研究中心美國冷泉港實驗室(Cold Spring Harbor Laboratory, New York, USA)進修。承擔細胞周期中具有重要作用的轉錄因子的研究課題，完成了這些因子的克隆、表達及功能的研究。1995年又曾以訪問學者的身份前往美國康奈爾大學醫學院附屬北岸醫院研究中心，運用RDA（Representational Difference Analysis）技術和基因差異顯示技術（Differential Display），篩選腫瘤細胞分裂過程中的關鍵新基因。1997年回國後，在北京大學醫學部基礎醫學院藥理學系建立了具有一定規模的分子藥理學研究室。開展了與疾病有關的基因缺陷的動物模型的建立與研究工作，同時還涉及離子通道、分子腫瘤及心血管分子藥理學等方面研究工作。、
研究方向
（1）採用基因敲除、基因敲入及轉基因等研究方法研究和建立疾病動物模型和藥理學研究模型；
（2）糖尿病和降血糖藥物的分子作用機制研究；
（3）抗腫瘤藥物及腫瘤發病機制的研究。
科研項目
國家十一五支撐計劃（2015.07.01-2017.12.31）；
課題名稱：科研用試劑產業鏈創新體系的構建
課題編號：2015BAK45B01
任務名稱：製劑產品的抗原物質檢測試劑盒研發及關鍵技術的研究
任務負責人：譚煥然
國家自然科學基金面上項目（2017.1.1-2020.12.31）
課題名稱：巨噬細胞介導的腫瘤轉移分子機制及潛在藥物作用靶點的研究
項目編號：81673459/H3105
項目負責人：譚煥然
學術成果
文章
1 Hui Li, Yiqing Mao, Qun Zhang, Qing Han, Zhenming Man, Jingyu Zhang, Xi Wang, Ruobi Hu, Xuehui Zhang, David M Irwin*, Gang Niu*, Huanran Tan*, Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy，Journal of Ethnopharmacology 2016，192，459–470 http://dx.doi.org/10.1016/j.jep.2016.08.031 （IF= 3.055）
2 Na Zhou, Yizhuang Zhang, Xuehui Zhang, Zhen Lei, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, David M. Irwin,* Gang Ni*, and Huanran Tan,* Exposure of Tumor-Associated Macrophages to Apoptotic MCF-7 Cells Promotes Breast Cancer Growth and Metastasis International Journal of Molecular Sciences. Int. J. Mol. Sci. 2015, 16, 11966-11982; doi:10.3390/ijms160611966 ( IF=2.339 5 year IF=2.721)
3 Na Zhou, Rong Wang（共同第一作者）, Yizhuang Zhang, Zhen Lei, Xuehui Zhang, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, David M. Irwin*, Gang Niu*, Huanran Tan,*Staurosporine induced apoptosis may activate cancer stem-like cells (CD44+/CD24-) in MCF-7 by upregulating mucin1 and EpCAM. Journal of Cancer 2015; 6(10): 1049-1057. doi: 10.7150/jca.12501 ( IF=3.271)
4 Ling Jin, Tingting Guo, Zhixin Li , Zhen Lei, Hui Li, Yiqing Mao, Xi Wang , Na Zhou, Yizhuang Zhang, Ruobi Hu, Xuehui Zhang, Gang Niu ,* David M. Irwin,* and Huanran Tan,*Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein. International Journal of Molecular Sciences. Int. J. Mol. Sci. 2015, 16, 7377-7393; doi:10.3390/ijms16047377 ( IF=2.339 5 year IF=2.721)
5 Hui Li, Xi Wang, Yiqing Mao, Ruobi Hu, Wei Xu, Zhen Lei, Na Zhou, Ling Jin, Tingting Guo, Zhixin Li, David M Irwin, Gang Niu* and Huanran Tan*, Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK. Cardiovascular Diabetology 2014,13(24).doi:10.1186/1475- 2840-13-24 ( IF=4.209，5 year IF=3.774)
6 Rong Wang, Hui Gao, Wei Xu, Hui Li, Yiqing Mao, Yi Wang, Tingting Guo, Xi Wang, Rongjing Song, Zhixin Li, David M. Irwina, Gang Niu and Huanran Tan.* Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice Gene 2013 516: 248-254 (IF=2.341, 5 years IF=2.443)
7 Xiaojing Zhang, Hui Li, Yiqing Mao, Zhixin Li, Rong Wang, Tingting Guo, Ling Jin, Rongjing Song, Wei Xu, Na Zhou, Yizhuang Zhang, Ruobi Hu, Xi Wang, Huakang Huang, Zhen Lei, Gang Niu, David M. Irwin，Huanran Tan*, An over expression APP model for anti-Alzheimer disease drug screening created by Zinc Finger Nuclease Technology. PLoS ONE8(11): e75493 doi:10.1371 / journal. pone. 0075493 ( IF=4.092，5 year IF=4.537)
8 Wei Xu, Hui Li, Rong Wang, Zhen Lei, Yiqing Mao, Xi Wang, Yizhuang Zhang, Tingting Guo, Rongjing Song, Xiaojing Zhang, Ling Jin, Zhixin Li, David M. Irwin*, Gang Niu, Huanran Tan*, Differential Expression of Genes Associated with the Progression of Renal Disease in the Kidneys of Liver-Specific Glucokinase Gene Knockout Mice. Int. J. Mol. Sci.( International Journal of Molecular Sciences) 2013, 14, 6467-6486; doi:10.3390/ijms14036467 ( IF=2.598，5 year IF=2.617 )
9 Rongjing Song, Xi Wang, Yiqing Mao, Hui Li, Zhixin Li, Wei Xu, Rong Wang, Tingting Guo, Ling Jin, Xiaojing Zhang, Yizhuang Zhang, Na Zhou, Ruobi Hu, Jianwei Jia, Zhen Lei, David M. Irwin, Gang Niu, Huanran Tan*, Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β 2013. Gene 529 (2013) 50–56(IF=2.341, 5 years IF=2.443)[1]