王歡(研究員)檢視原始碼討論檢視歷史
王歡,女,北京大學基礎醫學院研究員。博士生導師。
人物履歷
2018.7 ~ 至今北京大學基礎醫學院系統生物醫學研究所副研究員
2014.9 ~ 2018.6 哈佛醫學院,系統生物學系,博士後(導師:Peter K. Sorger)
2013.5 ~ 2014.9 科羅拉多大學波爾德分校,化學與生物工程系,博士後(導師:Kristi S. Anseth)
2006.9 ~ 2013.5 科羅拉多大學波爾德分校,分子,細胞與發育生物學系,博士(導師: Leslie A. Leinwand and Kristi S. Anseth)
2004.9 ~ 2005.6 香港中文大學, 生物系, 交換學生
2002.9 ~ 2006.7 浙江大學,生物技術系,學士
研究方向
包括抗腫瘤藥物引起心臟毒性的機制及潛在靶點,多組學數據的整合分析,微環境理化因子的調控機制。
學術任職
目前擔任中國病生理學會系統生物醫學青年專委會委員。
學術成果
Representative publications (代表性論文):
1. Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Alison RE, Maliszewski L, Haigis MC, Sorger PK. Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Syst 8, 412-426.e7 (2019).
2. Wang H, Tibbitt MW, Langer SJ, Leinwand LA and Anseth KS. Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway. Proceedings of the National Academy of Sciences USA, 110 (48): 19336-19341 (2013).
3. Wang H, Leinwand LA and Anseth KS. Cardiac valve cells and their microenvironment—insights from in vitro studies, Nature Reviews Cardiology, 11(12):715-727 (2014).
4. Wang H, Leinwand LA and Anseth KS. Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation, The FASEB Journal, 28(10):4551-4562 (2014).
5. Wang H, Haeger SM, Kloxin AK, Leinwand LA and Anseth KS. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS ONE, 7(7):e39969 (2012).
6. Wang H, Sridhar B, Leinwand LA, Anseth KS. Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves. PLoS ONE, 8(7): e69667. [1]