於 宇檢視原始碼討論檢視歷史
於 宇,女,北京大學基礎醫學院教授。
研究方向
腫瘤發生和發展的表觀遺傳機制、蛋白質翻譯後修飾對發育和腫瘤轉移的調控機制
獲得基金
1、國家自然科學基金面上項目,2021-2024。
2、北京市自然科學基金面上項目,2019-2021。
3、國家自然科學基金面上項目,2016-2019。
4、北京市高校「青年英才」計劃,2014-2015。
5、國家自然科學基金青年項目,2012-2014。
6、教育部博士點青年基金,2012-2014。
7、臨床醫學+X青年專項項目(+延續),2021-2022。
授權專利
專利名稱:一種特異性長效RNA在製備治療乳腺癌的藥物中的用途
專 利 號:ZL201911107610.0
批准號、公告號:CN 110664831 B
授權公告日:2020-11-20
學術成果
論文
1. Yenan Fu, Xi Zhang, Xiao Liu, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu* and Hongquan Zhang*. The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis. Signal Transduction and Targeted Therapy 2022 Mar 21;7(1):81. doi: 10.1038/s41392-022-00896-1.
2. Wenhui Chu, Xi Zhang, Lihua Qi, Yenan Fu, Peng Wang, Wei Zhao, Juan Du, Jing Zhang, Jun Zhan, Yunling Wang, Wei-Guo Zhu, Yu Yu* and Hongquan Zhang*. The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer. Cancer Res July 1 2020 80(13) 2737-2750; DOI: 10.1158/0008-5472.
3. Lihua Qi, Xiaochun Chi, Xueqian Feng, Shengchang Zhang, Junzhou Wu, Yao Song, Youyi Zhang, Wei kong, Yu Yu*, Hongquan Zhang*. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell Death & Disease 2019 Nov 26;10(12):890. doi: 10.1038/s41419-019-2121-0.
4. Peng Wang, Wenhui Chu, Xi Zhang, Bing Li, Junzhou Wu, Lihua Qi, Yu Yu*, Hongquan Zhang*. Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development. Int J Biochem Cell Biol. 2018; 105:41‐51. doi:10.1016/j.biocel.2018.09.022.
5. Yu Yu, Junzhou Wu, Yunling Wang, Ting Zhao, Bo Ma, Yuqing Liu, Weigang Fang, Wei-Guo Zhu & Hongquan Zhang. Kindlin-2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signaling. EMBO reports 2012 Aug;13(8):750-8. doi: 10.1038/embor.2012.88.
6. Yu Yu, Junzhou Wu, Lizhao Guan, Lihua Qi, Yan Tang, Bo Ma, Jun Zhan, Yunling Wang, Weigang Fang, and Hongquan Zhang. Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family. International Journal of Cancer 2013 Sep 15;133(6):1368-79. doi: 10.1002/ijc.28151.[1]