檢視盐酸阿糖胞苷的原始碼

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药品名称；盐酸阿糖胞苷

外文名；Cytarabine Hydrochloride

分子量；279.68

别    名；胞嘧啶阿拉伯糖苷

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本品为连接有糖的脱氧胞嘧啶相似物，其2位羟基可产生空间障碍，妨碍嘧啶碱基绕着核苷酸键的旋转，使多阿糖胞苷酸的碱基不能象多脱氧核苷酸那样正常地堆积起来。本品在体内必须先经活化才能起[[作用]]，即需在脱氧胞嘧啶激酶的催化下先转化为5-磷酸核苷酸（Ara-CMP），Ara-CMp能与合适的核苷酸激酶反应形成[[二磷酸]]和三磷酸核苷酸（Ara-CDP和Ara-CTP）。Ara-CTP的积聚可强烈抑制许多细胞的DNA合成，过去认为这是Ara-CTP竞争性抑制DNA多聚酶的结果。<ref>[http://ask.39.net/question/32901963.html 盐酸阿糖胞苷  ],39健康网 , 2014-07-25</ref>