陳揚
人物履歷
2018—至今 副研究員（Tenure track）：北京大學醫學部精準醫療多組學研究中心（副主任）／基礎醫學院
2016—2018 副研究員：清華大學生命科學學院
2014—2016 助理研究員：清華大學生命科學學院
2012—2014 博士後：清華大學生命科學學院（合作導師：俞立）
2008—2012 博士：北京大學醫學部基礎醫學專業（美國國立衛生研究院）
（導師：柯楊、Matthias Machner）
2004—2008 本科：北京大學醫學部基礎醫學專業
研究領域
主要從事膜性細胞結構和細胞器生物膜動態變化的研究。研究外泌體、新細胞器遷移體等細胞外囊泡發生、物質分選運輸、細胞間信號溝通的分子細胞生物學機制。應用蛋白質譜技術定量鑑定疾病樣品中遷移體、外泌體的內容物，探索細胞外囊泡在疾病中的重要作用及疾病診斷中的功能。
學術成果
論文
研究性論文：「*」代表第一作者；「#」代表責任作者
1. Yang Chen*, Nan Zhang*, Jie Zhang*, Jiangtao Guo*, Shaobo Dong*,Heqiang Sun, Shuaixin Gao, Tingting Zhou, Min Li, Xueyuan Liu, Yaxin Guo, Beiwei Ye, Yingze Zhao, Tongqi Yu, Jianbo Zhan, Yongzhong Jiang,Catherine CL Wong#, George F. Gao#, William J. Liu#. Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochimica et Biophhysica Acta proteins and proteomics . 2022 Feb 1; 1870(2): 140736. Epub ahead of print. ( Cover story )
2. Wenmin Tian*, Delin Li*, Nan Zhang*, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen#, Catherine C L Wong#, George Fu Gao#. O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule. Cell Research . 2021 Oct;31(10):1123-1125.
3. Yang Chen*, Hangping Yao*, Nan Zhang*, Jie Wu*, Shuaixin Gao, Jiangtao Guo, Xiangyun Lu, Linfang Cheng, Rui Luo, Xue Liang, Catherine CL Wong#, Min Zheng#. Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage. The Journal of Proteome Research . 2021 Jul 2;20(7):3463-3474
4. Wenmin Tian*, Nan Zhang*, Ronghua Jin*, Yingmei Feng*, Siyuan Wang*, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen#, George, Fu Gao#, and Catherine CL Wong#(corresponding author). Immune suppression in the early stage of COVID-19 disease. Nature Communications . 2020, 11(1):5859.
5. Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu#, Xiaoguang Lei#, Yang Chen# (2020). Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discovery , 2020 Aug 4;6:51.
6. Xiaoxin Zhao*, Yaxin Lei, Jiajia Zheng, Junya Peng, Ying Li, Li Yu#, and Yang Chen# (2019). Identification of markers for migrasome detection. Cell Discovery , 2019 May 21;5:27. (co-corresponding author)
7. Mi N*, Chen Y*, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z, Yu L. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology . 2015 Jan; 25(1): 24-38 (co-first author)
8. Du W*, Su QP*, Chen Y*, Zhu Y, Jiang D, Rong Y, Zhang S, Zhang Y, Ren H, Zhang C, Wang X, Gao N, Wang Y, Sun L, Sun Y, Yu L. Kinesin 1 Drives Autolysosome Tubulation. Developmental Cell . 2016 May 23; 37(4): 326-36 (co-first author)
9. Neunuebel MR*, Chen Y*, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science . 2011 Jul 22; 333(6041): 453-6 (co-first author)
10. Chen Y*, Tascón I*, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A. Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLOS Pathogen . 2013 May 16; (co-first author)
11. Chen Y*, Machner MP. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infection and Immunity . 2013 Jun 881(6): 2226-35
綜述和評論性文章：
1. Chen Y*, Su Q*, Sun YJ, Yu L. Visualizing autophagic lysosome reformation in cells using in vitro reconstitution systems. Current Protocols in Cell Biology , 2018 Mar;78(1):11.24.1-11.24.15.
2. Chen Y*, Li Y, Ma L, Yu L. Detection of migrasomes. Cell Migration: Methods and Protocols, Methods in Molecular Biology , vol. 1749, 2018
3. Chen Y*, Li Y. Development of research into autophagic lysosome reformation. Molecules and Cells . 2018 Jan 31;41(1):45-49.
4. Yu L, Chen Y, Tooze SA. Autophagy pathway: cellular and molecular mechanisms. Autophagy . 2017 Sep 21:1-9.
5. Chen Y*, Yu L, Recent progress in autophagic lysosome reformation. Traffic . 2017 Jun; 18(6): 358-361.
6. Chen Y*, Yu L, Research progress of membranous organelles and their subcellular structures in China. Chinese Science Bulletin 2017 May 12;
7. Chen Y*, Yu L, Scissors for autolysosome tubules. EMBO J . 2015 Sep 2; 34(17): 2217-8.
8. Chen Y*, Yu L. Autophagic lysosome reformation. Exp Cell Res . 2013 Jan 15;319(2):142-6
9. Machner MP*, Chen Y, Catch and release: Rab1 exploitation by Legionella pneumophila. Cell Logist . 2011 Jul 1; 1(4): 133-138.[1]