陳偉 ( 教授 )
人物簡歷
教育經歷
[1].2002.9 -- 2006.7
北京航空航天大學 生物工程 本科 學士
[2].2006.9 -- 2011.7
中國科學院北京基因組研究所 遺傳學 研究生 博士
工作經歷
[1].2011.9 -- 2015.12
中國科學院北京基因組研究所 助理研究員
[2].2016.1 -- 2020.4
中國科學院北京基因組研究所 副研究員
[3].2020.4 -- 至今
北京航空航天大學 醫工交叉創新研究院 副研究員
研究方向
[1] 群體遺傳學 a. 複雜疾病的遺傳易感性 b. 人類微進化及適應性表型的遺傳基礎解析 [2] 分子細胞遺傳學 a. 體細胞突變的發生、演進、分布特性、功能影響的系統性研究 b. 單細胞組學解析組織細胞異質性與複雜表型的關聯
研究成果
1、建立人類胚胎髮育期體細胞突變特徵譜，並發現低氧誘導因子激活導致的特異性突變模式；
2、應用單細胞組學發現局部低氧環境導致的成纖維細胞轉分化在近視發生中的重要作用。
論文
(1) Deng Wu#, Yunao Liu#, Wei Chen*, Jianming Shao, Pubu Zhuoma, Dexiong Zhao, Yang Yu, Tianzi Liu, Ruoxuan Yu, Yongna Gan, Baima Yuzheng, Yongshu Huang, Haikun Zhang, Xiaoman Bi, Chengcheng Tao, Shujuan Lai, Qiaoxia Luo, Dake Zhang, Hongmei Wang, Pingcuo Zhaxi, Jianqing Zhang, Jie Qiao, Changqing Zeng*, How placenta promotes the successful reproduction in high-altitude populations: a transcriptome comparison between adaptation and acclimatization, Molecular Biology and Evolution, 2022;, msac120,
(2) Yaqiang Hong#, Dake Zhang#, Xiangtian Zhou#, Aili Chen#, Amir Abliz#, Jian Bai, Liang Wang, Qingtao Hu, Kenan Gong, Xiaonan Guan, Mengfei Liu, Xinchang Zheng, Shujuan Lai, Hongzhu Qu, Fuxin Zhao, Shuang Hao, Zhen Wu, Hong Cai, Shaoyan Hu, Yue Ma, Junting Zhang, Yang Ke, Qianfei Wang, Wei Chen*, Changqing Zeng*; Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia, Genomics, Proteomics & Bioinformatics. 2021. doi: 10.1016/j.gpb.2021.09.005
(3) Fuxin Zhao#; Hui Zhou#; Wei Chen#; Chenchen Zhao; Yangyang Zheng; Yijin Tao; Miaozhen Pan; Peter S.Reinach; Jiadi Zhua; Jianhong An; Runxia Lu; Jiang-fan Chen; Huifang Tang; Changqing Zeng; Jia Qu; Xiangtian Zhou*; Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression, Experimental Eye Research. 2021.11(212)
(4) Liang Wang#; Xiaonan Guan#; Qingtao Hu#; ZhenWu#; Wei Chen#; Lairong Song; Ke Wang; Kaibing Tian; Chunwei Cao; Dake Zhang; Junpneg Ma; Xiangjun Tong; Bo Zhang; Juting Zhang*; Changqing Zeng C*; TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7. Carcinogenesis. 2021.04(42):913-923.
(5) Wei Chen#; Ke Zhang#; Peiling Dong#; Gregory Fanning; Chengcheng Tao; Haikun Zhang; Shicheng Guo; Zheng Wang; Yaqiang Hong; Xiaobo Yang; Shujuan Lai; Huiguo Ding; Haitao Zhao; Changqing Zeng*; Ulrike Protzer*; Dake Zhang*; Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer, Hepatology International, 2020.05 (14):326-337.
(6) Zhenglin Du#; Liang Ma#; Hongzhu Qu#; Wei Chen#; Bing Zhang#; Xi Lu; Weibo Zhai; Xin Sheng; Yongqiao Sun; Wenjie Li; Meng Lei; Qiuhui Qi; Na Yuan; Shuo Shi; Jingyao Zeng; Jinyue Wang; Yadong Yang; Qi Liu; Yaqiang Hong; Lili Dong; Zhewen Zhang; Dong Zou; Yanqing Wang; Shuhui Song; Fan Liu; Xiangdong Fang; Hua Chen; Xin Liu; Jingfa Xiao*; Changqing Zeng*; Whole genome analysis of Chinese population and de novo assembly of a northern Han genome, Genomics Proteomics & Bioinformatics,2019.09.17(3):229-247.
(7) Hao Wu#; Wei Chen#; Fei Zhao#; Qingyi Zhou; Reinach Peter S; Lili Deng; Li Ma; Shumeng Luo; Srinivasalu Nethrajeith; Miaozhen Pan; Yang Hu; Xiaomeng Pei; Jing Sun; Ran Ren; Yinghui Xiong; Zhonglou Zhou; Sen Zhang; Geng Tian; Jianhuo Fang; Lina Zhang; Jidong Lang; Deng Wu; Changqing Zeng*; Jia Qu J*; Xiangtian Zhou*; Scleral hypoxia is a target for myopia control, Proceedings of the National Academy of Sciences of the United States of America, 2018.07.24;115(30):E7091-E7100.[1]