钱旭红

钱旭红，男，1962年生于江苏宝应，长江学者、博导、教授、“973”首席科学家、中国工程院院士、国家自然科学基金化学部咨询委员、英国皇家化学会会士、德国洪堡基金会学术大使。 2011年当选中国工程院院士，曾任华东理工大学校长。 现任华东师范大学校长、党委委员、常委、党委副书记。 中文名 钱旭红 国 籍 中国 民 族 汉族 出生地 江苏宝应 出生日期1962年 职 业 科学家 毕业院校华东化工学院（现华东理工大学） 主要成就 1996国务院政府特殊津贴 1998中国青年科技奖； 1999第六届上海十大科技精英 2011年当选中国工程院院士 亚洲及太平洋化工联盟主席 展开

钱旭红
原图链接 [1] 钱旭红
出生	1962年 江苏宝应
国籍	中国
职业	科学家

目录 1 人物生平 2 研究方向 3 主要成就 ▪ 获得荣誉 ▪ 研究成果 4 学术论文

目录

人物生平

1978.9——1982.7，

钱旭红院士华东化工学院（现华东理工大学）石油化工系学习，获学士学位； 1982.9——1985.4，华东化工学院（现华东理工大学）精细化工系学习， 获硕士学位； 1988.7，获华东理工大学工学博士学位； 1989.8——1990.8，受美国Welch基金会资助，到美国德克萨斯州拉玛大学Research Associate，从事博士后研究，期间他从事了昆虫生长调节剂的研究工作； 1990.9——1991.12，德国巴伐利亚州维尔兹堡大学洪堡基金（AvH）博士后，从事DNA嵌入剂、切断荆的研究； 1988——1992.4，华东理工大学讲师； 1992.8——1994.7，副教授； 钱旭红和杨贤金于华东理工大学 钱旭红和杨贤金于华东理工大学 1994.8至今，教授； 1995.12至今，博士生导师； 1986——1987，华东理工大学精细化工系党总支副书记； 1992.8——1995.4，先后任华东理工大学精细化工学科主任、药物化工研究所所长； 1995.5——1995.7，国家高级教育行政学院学员； 1995.9——1996.2，华东理工大学校长助理； 1996.3——2000.10，华东理工大学副校长； 2000.9——2004.6，大连理工大学教育部长江学者奖励计划特聘教授； 2002.1——2010.1，上海市化学生物学重点实验室主任（兼）； 钱旭红院士卸任华东理工大学校长（2015年3月） 钱旭红院士卸任华东理工大学校长（2015年3月） 2003.3——2006，国家南方农药创制中心（上海）主任（兼）； 2004.7——2015.3，华东理工大学校长； 2007.4——，中国化工学会副理事长； 2007——2008，亚洲及太平洋化工联盟主席； 2011.12，当选中国工程院院士（化工、冶金与材料工程学部）； [4] 2018.1——，华东师范大学校长、党委委员、常委、党委副书记。 [2-3] [5-6]

研究方向

钱旭红主要研究方向，包括：是生物有机化学，化学生物技术与工程，其研究工作主要体现在用作农药先导、荧光传感器、抗癌先导、人工核酸酶、细胞激活剂的芳香杂环分子设计、合成、构效关系及生物应用。具体研究方向： 研究方向1.染料的化学生物学 其研究主要体现在荧光传感器与抗癌先导，

钱旭红院士包括以下内容： 荧光传感器：由萘，萘酰亚胺，香豆素，氟硼吡咯，聚合物衍生的高选择性汞离子铜离子锌离子银离子荧光传感器，某些阴离子荧光传感器，以及其它的荧光探针，荧光标记。 抗癌先导：由硫化合物，噻类芳香杂环，羰酰亚胺，萘酰亚胺，萘内酰胺、苯并吲哚酚嗪，吖啶，苊萘醌，苊萘吡咯羰腈，酞菁等衍生的抗癌试剂，BCL蛋白与细胞调亡剂，拓扑异构酶抑制剂、光动力治疗剂，色素的药物化学（抗肿瘤先导、DNA嵌入剂、细胞调亡剂） 研究方向2.农药的化学与生物学 其研究主要体现在芳香杂环或氟化合物衍生的农药先导，包括以下内容： 农药先导：昆虫生长调节剂、昆虫行为调节剂、几丁质合成抑制、蜕皮激动、飞行调控、海藻糖酶抑制，拒食，尼古丁受体激动，杀虫剂，除草剂，杀菌剂。 新杂环化合物：氟化合物，氟烷氧基化合物，芳香杂环，硫化合物，恶二唑、噻二唑、哒嗪酮、新烟碱、环亚胺、二芳酰基肼 研究方向3. 化学生物技术与工程 其研究主要体现在人工核酸酶，

钱旭红院士细胞激活剂和生物转化，包括以下方面： 人工核酸酶：由萘酰亚胺、硫杂环衍生的人工光核酸酶，光降解，人工核酸水解酶，DNA切断剂，生物制备过程中转基因物质的去除。 细胞激活剂：由茉莉酮酸酯、苯并噻二唑等衍生的细胞激活剂，用于人参、紫杉烷、灵芝的次生代谢物的增产与调控。 生物转化：酵母，植物细胞，立体选择性还原，化学选择性还原，芴，芳香硝基、胺、羟胺、酮还原、手性醇。

主要成就

获得荣誉 1992 霍英东基金会高校优秀青年教师奖（科研类）； 钱旭红院士就任华东师范大学校长（2018年1月） 钱旭红院士就任华东师范大学校长（2018年1月） 1995 全国优秀教师； 1996 国务院政府特殊津贴； 1997 入选国家百千万人才工程（第一、二层次）； 1998 中国青年科技奖； 1999 第六届上海十大科技精英； 1994 国家教委科技进步一等奖（第二完成人）； 1998 上海市科技进步三等奖（第一完成人）； 1998 国家教育部科技进步一等奖（第一完成人）； 2002 国家教育部科技进步一等奖（第一完成人）； 2003 国家教育部自然科学一等奖（第一完成人）。 2000 国家杰出青年科学基金获得者； 2001 大连市优秀专家； 2001- 中国化工学会农药委员会副主任委员。J. Fluorine Chemistry,Pesticide Biochemistry and Physiology等编委，在ChemCommun.,Org.Lett.,JACS等 SCI 国际学报发表论文近百十篇。专利十数项。此外， 2003 担任国家重点基础研究发展规划（973计划) 项目首席科学家； 2003- 国务院学位委员会学科评议组成员； 2004- 国家自然科学基金委员会第十届有机化学评议组成员，第十一届化工评议组成员。 2007. 3- 亚洲及太平洋化工联盟主席。 2011 中国工程院院士

研究成果

上地幔变形作用和地球化学性质之间的关系及其深部动力学意义。 原华东理工大学校长、现华东师范大学校长钱旭红院士 原华东理工大学校长、现华东师范大学校长钱旭红院士 运用综合研究方法，探讨了伊通新生代玄武岩中特有的具糜棱结构的橄榄岩包体所经历的构造热演化及动力学，证实了上地幔韧性剪切带的存在。强调其形成与超大断裂活动性之间的关系；并首次发现了橄榄岩包体中矿物颗粒间的氧同位素不平衡现象，为地幔剪切变形和地幔交代作用提供了时间约束，认为流体的存在并不是剪切变形的先决条件，从而为地幔学术界长期争论的流体和地幔变形之间的因果关系提供了新的判别依据。根据吉林汪清尖晶石相橄榄岩包体结构、平衡温度、主元素亏损程度和不相容元素富集程度之间的相关关系，提出了上地幔底辟上升和热扩散平衡的动力学模式，阐明了不同结构类型包体在底辟体中的空间展布及其对交代流体迁移的控制。认为所有研究样品均来自岩石圈地幔，但由于下伏软流圈的上涌而导致其流变学性质的改变，从而同软流圈一起发生底辟。这一成果为华北自中生代以来发生的大规模热侵蚀-减薄机制提供了一个可行的动力学模式。 上地幔熔体-岩石反应机理及其微量元素理论模拟通过对伊通含富钾硅酸盐玻璃体的异剥橄榄岩和法国中央高原具镶嵌结构I型尖晶石相方辉橄榄岩包体的研究，橄榄岩包体的研究，鉴定出了单斜辉石生成反应和橄榄石生成反应两个系列。这是对构造橄榄岩体研究的重要补充，对地幔不均一性及岩浆源区混合作用的研究具有重要意义。后者还提供了岩石圈最底部-地幔热柱相互作用的证据。运用0-维数值模型计算了微量元素在上地幔熔体迁移/反应过程中地球化学行为。该成果对认识熔体/流体在深部岩石圈地幔演化过程中的作用具有重要意义。 地幔地质温压计的检测，应用和中国东部地幔岩石圈热演化系统总结和科学评价了常用的二十多种温度计和五种压力计的优缺点，为国内学者更加审慎地选用温压计提供了依据，在此基础上，探讨了中国东部上地幔热结构和热演化历史。以在特定热演化阶段中古老岩石圈/软流圈相互作用程度为思路，结合实验岩石学资料和岩石圈拉张历史，提出了一个热-构造演化模式，从而比较合理地解释了中国东部中生代末期-新生代玄武岩的岩性，微量元素和同位素地球化学演化特征，为深部地幔研究提供了新思路。 中国东部幔源橄榄岩的铂族元素地球化学研究在国内率先开展了中国东部幔源橄榄岩的PGE地球化学研究，填补了中国在地幔岩PGE研究领域的空白。初步了解了不同类型岩石中这些元素的丰度和分布规律，揭示了中国东部上地幔特有的PGE分配型式（即富集Pt，亏损Ir和Pd）。探讨了PGE在多种重要上地幔过程中的地球化学行为。

学术论文

研究方向1.染料的化学生物学 ORG. LETT.-2006-3721: A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity ORG. LETT. 2005-3029: Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu（Ⅱ）-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore ORG. LETT.-2005-889: Ratiometric and selective fluorescent sensor for Cu-Ⅱ based on internal charge transfer (ICT) ORG. LETT. 2004-2757: Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide (SS) J. ORG. CHEM.-2006-4308: Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity J. ORG. CHEM.-2007-3554: Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: A new strategy to discriminate cadmium from zinc CHEM. COMMUN.-2006-109: Two regioisomeric and exclusively selective Hg（Ⅱ） sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor CHEM. COMMUN.-2005-239: A new class of long-wavelength fluorophores: strong red fluorescence,convenient synthesis and easy derivation CHEM. COMMUN.-2001-2656: Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation NEW J. CHEM.-2003-337: A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cations NEW J. CHEM.-2002-920: Novel heterogeneous PET fluorescent sensors selective for transition metal ions or protons: polymers regularly labelled with naphthalimide J. AM. CHEM. SOC.-2004-2272: A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution KIDNEY INTERNATIONAL-2004-2279: Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells CHEM. RES. TOⅪC.-2005-1814: Visible study of mercuric ion and its conjugate in living cells of mammals and plants CHEMBIOCHEM-2007-113: Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents (SS) J. MATER. CHEM. -2005-2836: A pH-resistant Zn（Ⅱ） sensor derived from 4-aminonaphthalimide: design,synthesis and intracellular applications MOL. CANCER THER.-2007-484: R16,a novel amonafide analogue,induces apoptosis and G2-M arrest via poisoning topoisomerase Ⅱ (SS) BIOORG. MED. CHEM. LETT.-2006-1562: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor BIOORG. MED. CHEM. LETT.-2005-5909: Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities BIOORG. MED. CHEM. LETT.-2005-4864: Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation,side chains,and substituent groups (SS) BIOORG. MED. CHEM. LETT.-2005-4864: Synthesis,antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains (SS) BIOORG. MED. CHEM. LETT.-2005-1139: Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA (SS) BIOORG. MED. CHEM. LETT.-2003-5427: Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-fused area and the difference in spectra,photochemistry and photobiological activity (SS) BIOORG. MED. CHEM.-2007-1356: Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation (SS) BIOORG. MED. CHEM.-2006-6962：Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity (SS) BIOORG. MED. CHEM.-2006-4639: Design,synthesis,and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution (SS) BIOORG. MED. CHEM. -2005-3149: Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis,antitumor evaluation,and DNA photocleavage (SS) BIOORG. MED. CHEM.-2005-1615: Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins (SS) TETRAHEDRON LETT.-2005-6289: A proton sponge-based fluorescent switch TETRAHEDRON LETT.-2004-3969: A novel chromatism switcher with double receptors selectively for Ag+ in neutral aqueous solution: 4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides TETRAHEDRON LETT.-2003-2087: Novel highly efficient fluoroionophores with a peri-effect and strong electron-donating receptors: TICT-promoted PET and signaling response to transition metal cations with low background emission TETRAHEDRON LETT.-2003-795: Promoting effects of the hydroxymethyl group on the fluorescent signaling recognition of anions by thioureas TETRAHEDRON LETT.-2002-2991: 4-Amino-1,8-dicyanonaphthalene derivatives as novel fluorophore and fluorescence switches: efficient synthesis and fluorescence enhancement induced by transition metal ions and protons TETRAHEDRON LETT.-2002-2995: Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient 'time-resolved' DNA photocleaver with long-wavelength (SS) TETRAHEDRON LETT.-2001-6175: N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects TETRAHEDRON LETT.-2000-7711: Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides TETRAHEDRON-2005-11895: Novel DNA bis-intercalators of isoquinolino[4,5-bc]acridines: design,synthesis and evaluation of cytotoxic activity TETRAHEDRON-2005-8717: Synthesis,antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains (SS) TETRAHEDRON-2005-6634: Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities (SS) TETRAHEDRON-2006-10117: Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission DYES PIGMENTS-2002-247: Synthesis and properties of oligonucleotides containing fluorescent ethenodeoxyadeno sine and ethenodeoxycytidine DYES PIGMENTS-2001-51: Absorption and fluorescence spectral properties of tetra (fluoroalkoxy) metallophthalocyanines (FF) DYES PIGMENTS-2001-43: Oxazolonaphthalimides and their hydroperoxides: photophysical and photobiological properties DYES PIGMENTS-2004-9: Benzothioxanthene dyes as fluorescent label for DNA hybridization: synthesis and application (SS) DYES PIGMENTS-2004-17: Synthesis and peroxidase-staining properties of novel water soluble polyhydroxylalkyl benzidine dyes J. FLUORINE CHEM.-2002-161: Synthesis and photosensitizing properties of fluoroalkoxyl phthalocyanine metal complexes (FF) J. FLUORINE CHEM.-2000-69: Synthesis of fluorine-containing oxazolonaphthalimide hydroperoxides as DNA photocleavers (FF) CHINESE J. ORG. CHEM.1997-329: Synthesis and characterizations of the dye sensitized photooxygenation products and the heterocycles of naphthofuran derivatives CHINESE J. ORG. CHEM.-1997-428: Synthesis,characterization and DNA intercalation of a furonaphthopyronone as a novel analogue of furocoumarin CHINESE J. ORG. CHEM.-2000-338: Synthesis and structure characterization of two thienonaphthopyrones (SS) CHINESE J. ORG. CHEM. 2006-504: Synthesis and properties of N-butyl-4-(aza-15-crown-5）-1,8-naphthalimide as a fluorescent probe CHEM. RESEARCH IN CHINESE UNⅣ.-2005-480: A novel photocleaver with long wavelength absorption - Highly efficient antitumor agent: 4-（2-diethylamino -ethylamino)-8-oxo-8H-acenaphtho-[ 1,2-b] pyrrole-9-carbonitrile CHEM. J. CHINESE UNⅣ.-1996-1399: Syntheses，DNA Intercalation Activities and Molecular Modelling on Structures of Tatramethyldifuronaphthalenes J. PHOTOCHEM. PHOTOBIO. B-2001-35: Tetra-trifluoroethoxyl zinc phthalocyanine: potential photosensitizer for use in the photodynamic therapy of cancer (SS) J. PHOTOCHEM. PHOTOBIO. B-2006-221: Isoquino[4,5-bc]acridines: Design,synthesis and evaluation of DNA binding,anti-tumor and DNA photo-damaging ability J. CHEM. SOC.-PERKIN TRANSACTIONS 2-2000-715: Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups (SS) MONATSH CHEM.-1999-1109: Synthesis of novel DNA-intercalating naphthopyrone derivatives with improved water solubility and photophysical properties BULL. CHEM. SOC. JAPAN-1999-1571: Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides CHEM. LETT.-2005-696: Novel naphthalimide fluorescent sensors selective for certain proteins on basis of non-covalent interactions between enzyme and inhibitor (SS) SYNTHESIS-STUTTGART-1999-1109: General synthesis of thioxo-1,8-naphthalimides via thioxo-1,8-naphthalic anhydrides (SS) HETEROATOM CHEM.-1999-141: The improved synthesis,Diels-Alder reactions,and desulfuration of trithio-1,8-naphthalic anhydride (SS) POLYMER-2002-5731: Synthesis and photophysical properties of 1,8-naphthalimide-labelled PAMAM as PET sensors of protons and of transition metal ions CHINESE J. ANAL. CHEM. -2004-837: Studies on the room temperature phosphorescence of halogen naphthalic anhydrides CHINESE CHEM. LETT.-2004-118: Anthracylmethyl benzoazacrown ether as selective fluorescence sensors for Zn2+ HETEROCYCL. COMMUN.-2003-229: A new class of DNA intercalator and photocleaver: Bis-naphthailimides with bromo and nitro substituents MONATSH. 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BIOENG.-2004-809: Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism BIOTECH. BIOENG.-2004-595: Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis BIOTECH. PROGR.-2006-331: Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites BIOTECH. AND BIOPROCESS ENGI.-2005-162: Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self-chemically-synthesized jasmonates BIOCHEM. ENGINEERING. J.-2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins TETRAHEDRON LETT.-2004-1247: Naphthalimide-thiazoles as novel photonucleases: molecular design,synthesis,and evaluation (SS) TETRAHEDRON-2005-11264: Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse Snar(H)H reactions,cytotoxicity and spectral behavior (SS) DYES AND PIGMENTS-1999-139: Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis [7] 词条图册 更多图册 参考资料 1. 杜慧芳曲景平分别任华东理工大学党委书记校长 ．网易[引用日期2015-03-16] 2. 钱旭红任华东师范大学校长、党委副书记 ．共产党新闻网[引用日期2018-01-17] 3. 钱旭红院士今出任华东师大校长，曾任华东理工大学校长11年 ．澎湃新闻[引用日期2018-01-17] 4. 钱旭红 ．人民网[引用日期2015-03-16] 5. 钱旭红 ．华东理工大学官网[引用日期2018-01-17] 6. 华东师范大学举行干部教师大会宣布校长任免决定 ．华东师范大学官网[引用日期2018-01-17] 7. 钱旭红 ．华东理工大学[引用日期2013-06-25] 词条标签： 科学家 ， 生物学家 ， 化学家 ， 人物

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词条统计 浏览次数：197377次 编辑次数：44次历史版本 最近更新：w_ou（2018-07-05） 突出贡献榜 LK爱问知识 热词版本 1 人物生平 2 研究方向 3 主要成就 3.1 获得荣誉 3.2 研究成果 4 学术论文