楊娟娟
人物簡歷
2019.06—至今 福州大學，生物科學與工程學院 副教授
2015.05—2019.05 福州大學，生物科學與工程學院 講師
2011.09—2015.04 廈門大學，化學生物學專業理學 博士
2011.04—2011.09 中國科學院上海藥物研究所交流學習
2008.09—2011.03 華東理工大學，製藥工程與技術專業工學 碩士
2004.09—2008.07 鄭州大學，製藥工程專業工學 學士
研究方向
科研項目
1. 國家自然科學基金（青年基金），人源程序性死亡受體PD-1與其配體PD-L2負性調控免疫應答的結構基礎研究，項目編號31700656，項目起止時間2018.01—2020.12，主持；
2. 福建省自然科學基金（青年基金），人程序性死亡配體PD-1與其配體PD-L2調節免疫應答的結構基礎和功能研究，項目編號2017J05050，項目起止時間 2017.04-2020.04，主持；
3. 福州大學校人才項目，人源B7家族PD-1-PD-L2通路調節免疫應答的結構基礎，項目起止時間2015.5—2017.5，主持。
學術成果
論文
1. Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-liang Ji, Donghai Lin*. Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis. Acta Biochim Biophys Sin, 2019, 51(2):139-149.
2. Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, Donghai Lin, Kejiang Lin*. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.Bioorganic Chemistry, 2019, 82: 58-67.
3. Yang Yang, Zhen Liu, Xiaoqin He, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai*, Wei Xu* and Lin Wei*. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. Journal of Biological Chemistry, 2019, 294(19): 7615-7631.
4. Taotao Chen, Zheng Chen, Huimin Wang, Xiaodong Chen, Juanjuan Yang, Aidong Han, Dong-Hai Lin, Jing Hong*. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective effects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018, 40: 606-613.
5. Juanjuan Yang, Yindi Liu, Shuli Xu, Haiying Lin, Chun Meng, Donghai Lin*. Expression, purification and characterization of the full-length SmpB protein from Mycobacterium tuberculosis. Protein expression and purification, 2018, 151: 9-17.
6. Juanjuan Yang, Lei Hu, Tiantian Cai, Qiuluan Chen, Qian Ma, Jie Yang, Chun Meng, Jing Hong*. Purification and identification of two novel antioxidant peptides from perilla (Perilla Frutescens L. Britton) seed protein hydrolysates. PLoS One, 2018, 13(7): 1-15.
7. Lixian Mu, Lei Zhou, Juanjuan Yang, Li Zhuang, Jing Tang, Tong Liu, Jing Wu, Hailong Yang*. The first identified cathelicidin from tree frogs possesses anti‑inflammatory and partial LPS neutralization activities. Amino Acids, 2017, 49: 1571-1585.
8. Juanjuan Yang, Yindi Liu, Zhao Liu, Chun Meng, Donghai Lin*. Backbone and side-chain resonance assignments for the tmRNA binding protein, SmpB, from Mycobacterium tuberculosis. Biomolecular NMR Assignments, 2017, 11(2): 175-179.
9. Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Molecular Microbiology, 2015, 95(5), 791-803.
10. Lin Wei, Chunjing Huang, Hailong Yang, Min Li, Juanjuan Yang, Xue Qiao, Lixian Mu, Fei Xiong, Jing Wu*, Wei Xu*. A potent anti-inflammatory peptide from the salivary glands of horsefly. Parasit Vectors, 2015, 8: 556-556.
11. Lin Wei§, Juanjuan Yang§, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan*, Donghai Lin*, Ren Lai*. Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial and Anti-inflammatory Peptide. J. Med.Chem. 2013, 56: 3546-3556(§, co-first author).
12. Li Dong§, JuanJuan Yang§, Ying Wang, Huan Liu, LiXian Mu, Donghai Lin*, Ren Lai*. Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. Nat. Prod. Bioprospect., 2012, 2: 81–86 (§, co-first author).
13. Juanjuan Yang, Huicai Huang, Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael–Michael Reaction. Synthesis, 2011, 12: 1984-1987.
14. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye. As*, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde. Synthesis, 2011, 7:1085-1091.
15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective Michael Reaction of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12: 5218-5221.
16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8: 3244-3250.
專利申請
1. 一種人源程序性死亡受體hPD-1單克隆抗體：楊娟娟，孟春，呂唯，劉照，吳茂，授權專利號 ZL 201611197005.3。
2. 一種人源程序性死亡因子配體hPD-L2單克隆抗體：楊娟娟，孟春，劉照，羅嶺，夏菁潞，徐淑麗授權專利號：2017102780143。
獲獎情況
1. 2018.11 福州大學生物科學與工程學院 青年教師「最佳一節課」教學競賽三等獎
2. 2017.11 指導全國大學生生命科學競賽 獲得三等獎
3. 2017.06 福州大學優秀本科畢業論文指導老師[1]