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戚正武

戚正武 [1]
生物化學家 男，1932年4月生，浙江寧波人。1952年畢業於同濟大學，1959年獲蘇聯醫學科學院莫斯科醫學生物化學研究所副博士學位。1999年當選為中國科學院院士。現為中國科學院上海生命科學研究院研究員。

戚正武
原圖鏈接來自中國科學院學部
出生 1932年4月 浙江寧波
國籍 中國
民族 漢
母校 同濟大學
職業 生物化學家
研究領域
醫學

目錄

人物經歷

  • 1952年畢業於同濟大學化學系；
  • 1959年獲蘇聯莫斯科醫學科學院生物與醫學研究所副博士學位；
  • 1981-1982年以及1987年、1995年分別於美國Purdue 及Notre Dame大學進行學術交流。曾擔任數屆國際《血栓研究》雜誌的編委，現任《中國科學》,《生物化學與生物物理學報》及其他國內多種學術期刊的編委。現兼同濟大學蛋白質研究所所長及化學系主任；
  • 1999年被評為中國科學院院士；
  • 2001年被評為第三世界科學院院士。

研究方向及科研成果

長期從事蛋白質、活性多肽、尤其是蛋白酶及其抑制劑的研究。系統研究了三種不同家族蛋白酶抑制劑的結構與功能，其中慈菇抑制劑為首先發現的新抑制劑家族，成為國際上研究蛋白酶抑制劑的重要研究中心之一。此外，協作克隆了凝血因子FVIII及vWF的全cDNA，並進行了表達。近年來又解析了中華馬氏鉗蠍毒素中多種Na+通道毒素的氨基酸序列及其基因結構，通過基因突變研究其結構與功能的關係，並開展了其它K+、Ca2+及Cl-通道神經毒素的研究。

主要獎項

  • 中科院自然科學一等獎一次，二等獎三次
  • 國家自然科學三等獎二次
  • 1981年慕尼黑國際激肽會議獲優秀論文獎及其他省、部級多次科技獎

代表性論文

  1. Yuan DD, Liu L, Shao XX, Peng C, Chi CW, Guo ZY. Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides. 2008 Sep;29(9):1521-5. Epub 2008 May 25.
  2. Wang Q, Jiang H, Han YH, Yuan DD, Chi CW. Two different groups of signal sequence in M-superfamily conotoxins. Toxicon. 2008 Apr;51(5):813-22. Epub 2007 Dec 15.
  3. Qian J, Guo ZY, Chi CW. Cloning and isolation of a Conus cysteine-rich protein homologous to Tex31 but without proteolytic activity. Acta Biochim Biophys Sin (Shanghai). 2008 Feb;40(2):174-81.
  4. Rui-feng Qi, Ling Zhang, and Cheng-wu Chi. Biological characteristics of dengue virus and potential targets for drug design. Acta Biochim Biophys Sin. 2008 Feb;40(2):91-101.
  5. Wang ZQ, Han YH, Shao XX, Chi CW, Guo ZY. Molecular cloning, expression and characterization of protein disulfide isomerase from Conus marmoreus. FEBS J. 2007 Sep;274(18):4778-87. Epub 2007 Aug 14.
  6. Yuan DD, Han YH, Wang CG, Chi CW. From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. Epub 2007 Mar 1.
  7. Du WH, Han YH, Huang FJ, Li J, Chi CW, Fang WH. Solution structure of an M-1 conotoxin with a novel disulfide linkage. FEBS J. 2007 May;274(10):2596-602. Epub 2007 Apr 16.
  8. Han YH, Wang Q, Jiang H, Liu L, Xiao C, Yuan DD, Shao XX, Dai QY, Cheng JS, Chi CW. Characterization of novel M-superfamily conotoxins with new disulfide linkage. FEBS J. 2006 Nov;273(21):4972-82. Epub 2006 Oct 17.
  9. Chen-Qi Xu, Shun-Yi Zhu, Cheng-Wu Chi and Jan Tytgat. Turret and pore block of K+Channels: what is the different? Trends Pharmac. Sci. 24(9): 446-449, 2003.
  10. Fan CX, Chen XK, Zhang C, Wang LX, Duan KL, He LL, Cao Y, Liu SY, Zhong MN, Ulens C, Tytgat J, Chen JS, Chi CW, and Zhou Z. A novel conotoxin from conus betulinus, k-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J Biol Chem. 278(15), 12624-12633, 2003.
  11. Wang CG, Gilles N, Hamon A, Le Gall F, Stankiewicz M, Pelhate M, Xiong YM, Wang DC and Chi CW. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry. 42 (16), 4699-4708, 2003.
  12. Wang CG, Stankiewicz M, Ling MH, Pelhate M, Wang DC and Chi CW*. Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch. J. Pept. Res. 61(1): 7-16, 2003.
  13. C. Goudet, Cheng-wu Chi, J Tytgat. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon. 40(9), 1239, 2002.
  14. Jiong Li, Kang-cheng Ruan, Cheng-wu Chi. The assignment of the reactive sites of the double-headed arrowhead proteinase inhibitor A and B. Acta Biochi. Biophys Sinica. 34, 662, 2002.
  15. Jiong Li, Cheng-wu Chi, Kang-cheng Ruan. Conformation nearby Trp residues of APIA and APIB modulates the inhibitory specificity of the protease. Acta Biochi. Biophys Sinica. 34, 494, 2002.
  16. Jing-Jiang Wu, Lin-Lin He, Zhuan Zhou and Cheng-Wu Chi. Gene expression, mutation and structure-function relationship of scorpion toxin BmP05 active on SKCa channels. Biochemistry. 41, 2844, 2002
  17. Chun Chen, Qi Wang, Xiang-dong Fang, Qin Xu, Cheng-wu Chi and Jian-xin Gu. Roles of the phytanoyl CoA ?-hydroxylase in mediating the expression of human coagulation factor VIII. J. Biol. Chem. 276, 46340, 2001.
  18. Guang-yu Zhu, Qi-chen Huang, Yan-shi Zhu, Cheng-wu Chi, You-qi Tang. X-ray study on an artificial mung bean inhibitor complex with bovine ?-trypsin in neat cyclohexane. Biochim. Biophys. Acta 1546, 98, 2001.
  19. Chun-Guang Wang, Xiao-Lin He, Feng Shao, Wei Liu, Min-Hua Ling, Da-Cheng Wang, Cheng-Wu Chi. Molecular characterization of an anti-epilepsy peptide from the scorpio Buthus martensi Karsch. Eur. J. Biochem. 268, 2480, 2001.
  20. Xiang-Dong Fang, Chun Chen, Qi Wang, Jian-Xin Gu, Cheng-Wu Chi. The Interaction of the Calcium and Integrin Binding Protein (CIBP) with the Coagulation Factor VIII. Thromb. Res. 102, 177, 2001.
  21. Hao Fei, Yan LI, Li-Xiu Wang, Ming-Juan Luo, Min-Hua Ling, Cheng-Wu Chi. Purified nonhistone protein from porcine kidney acts as a suicide substrate inhibitor on furin-like enzyme. Acta Pharmacol. Sin. 21, 265, 2000.
  22. Li Dai, Jing-jiang Wu, Yi-hua Gu, Zheng-dao Lan, Min-hua Ling and Cheng-wu Chi. Genomic organization of three novel toxins from the scorpion Buthus martinsi Karsch that are active on potassium channels. Biochem. J. 346, 805, 2000.
  23. Jing-jiang Wu, Li Dai, Zheng-dao Lan and Cheng-wu Chi. The Gene Cloning and Sequencing of Bm-12, a Chlorotoxin-like Peptide from the Scorpion Buthus martinsi Karsch. Toxicon 38, 661, 2000.
  24. Feng Shao, Yu-mei Xiong, Rong-huan Zhu, Min-hua Ling, Cheng-wu Chi & Da-cheng Wang. Expression and Purification of the BmK M1 Neurotoxin from the Buthus martinsi Karsch. Protein Expression and Purification 17, 358, 1999.
  25. Yan-shi Zhu, Qi-chen Huang and Cheng-wu Chi. Crystal structure of mung bean inhibitor lysine active fragment complex with bovine beta-trypsin at 1.8A resolution. J Biomol Struct Dyn. 1999 Jun;16(6):1219-24.
  26. Chun Chen, Xiao-dong Fang, Jiang Zhu, Xiang-fu Wu, Zu-chuan Zhang, Zheng-yi Wang and Cheng-wu Chi. The Gene Expression of Coagulation Factor VIII in Mammalian Cell Lines. Thrombosis Res. 95, 105, 1999.
  27. Jing-jiang Wu, Li Dai, Zheng-dao Lan and Cheng-wu Chi. Genomic Organization of Three Neurotoxins Active on Small Conductance Ca++-activated Potassium Channels from the Scorpion Buthus martinsi Karsch. FEBS Letters 452, 360, 1999.
  28. Yu-mei Xiong, Zheng-dao Lan, Miao Wang. Bo Liu, Xin-qi Liu, Hao Fei, Lai-gen Xu, Qi-Chang Xia, Chung-guang Wang, Da-cheng Wang and Cheng-wu Chi. Molecular Characterization of a New Excitatory Insect Neurotoxin with an Analgesic Effect on Mice from the Scorpion Buthus martinsi Karsch. Toxicon 37, 1165, 1999.
  29. Zheng-dao Lan, Li Dai, Xiao-liang Zhuo, Ke Xu, Jun-Cai Feng and Cheng-wu Chi. Gene Cloning and Sequencing of BmK AS and BmK As-1, Two Novel Neurotoxins from the Scorpion Buthus martinsi Karsch. Toxicon. 37, 815, 1999.
  30. Yu-mei Xiong, Min-hua Ling, Zheng-dao Lan, Da-cheng Wang and Cheng-wu Chi .The cDNA Sequence of an Excitatory Insect Selective Neurotoxin from the Scorpion Buthus martinsi Karsch. Toxicon 37, 335, 1999.
  31. Yu-mei Xiong, Min-hua Ling, Da-cheng Wang and Cheng-wu Chi. The cDNA and Genomic DNA Sequences of a Mammalian Neurotoxin from the Scorpion Buthus martensii Karsch. Toxicon 35, 1025, 1997.
  32. Ming-juan Luo, Yu-mei Xiong, Miao Wang, Da-cheng Wang and Cheng-wu Chi. Purification and Sequence Determination of a New Neutral Mammalian Neurotoxin from Scorpion Buthus martensii Karsch. Toxicon 35, 723, 1997.
  33. Ming-juan Luo, Wu-yuan Lu and Cheng-wu Chi. Clarification of an Uncertain Intron within the cDNA Sequences of Arrowhead Proteinase Inhibitor A and B. J. Biochem. (Tokyo) 121, 991, 1997.
  34. Zhi-wei Xie, Ming-juan Luo, Wen-feng Xu and Cheng-wu Chi. Two Reactive Site Location and Structure-Function Study of the Arrowhead Protease Inhibitors,A and B, Using Mutagenesis. Biochemistry (US) 36, 5846, 1997.

參考資料

  1. ↑ [1]中國科學院

外部鏈接

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