全軍民
人物履歷
2015- 北京大學深圳研究生院，教授
2006-2014 北京大學深圳研究生院，副教授
2004-2006 北京大學深圳研究生院，博士後
2000-2004 香港科技大學，博士
1997-2000 中山大學，碩士
1993-1997 北京大學，學士
獲獎情況
2010 北京大學百人計劃
2008 深圳市雙百人才計劃
研究興趣
我們應用計算化學、生物化學、以及結構生物學等多種手段深入研究生命活動中重要蛋白質調控的分子水平機制，特別是研究腫瘤相關信號通路中關鍵蛋白質的相互作用，細胞周期調控中蛋白激酶自身不同結構域之間、或者蛋白激酶與其調控蛋白質之間的相互作用，以及在重要信號通路（如WNT通路)中配體與受體的相互作用，並在結構基礎上研究阻斷或者促進這些相互作用的小分子調控劑。
學術成果
1. Chen Shen, Hong Yue, Jianwen Pei, Xiaomin Guo, Tao Wang*, Junmin Quan* 「Crystal structure of the death effector domains of caspase-8」 BBRC, 2015, 463, 297–302.
2. Hong Yue, Feng Lu, Chen Shen, Junmin Quan* 「Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway」 Bioorg. Chem. 2015, 61, 21–27.
3. Hongmei Shan, Yanxia Shi, Junmin Quan*. 「Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1」 ChemMedChem. 2015, 10, 158-163. 4. Hongmei Shan, Tao Wang*, Junmin Quan*. 「Crystal structure of the Polo-box Domains of Polo-like Kinase 2」 BBRC, 2015, 456, 780–784.
5. Jun Xu, Chen Shen, Tao Wang*, Junmin Quan* 「Structural basis for the inhibition of Polo-like kinase 1」 Nat. Struct. Mol. Biol. 2013, 20, 1047-53. (Highlighted in cover and also by Nature China, 2 October 2013 | doi:10.1038/nchina.2013.92)
6. Dai L, Liu Y, Liu J, Wen X, Xu Z, Wang Z, Sun H, Tang S, Maguire AR, Quan J*, Zhang H*, Ye T*. 「A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy.」 Cancer Lett. 2013, 333, 103-112.
7. Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan*, Tao Ye*, Hui Zhang*. 「Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties」 Cancer Res. 2011, 71, 7238-49. (Highlighted by Nature China, 4 January 2012 | doi:10.1038/nchina.2012.1)
8. Xiaolei Wang, Junmin Quan* 「Intermediate-Assisted Multifunctional Catalysis in the Conversion of Flavin to 5,6-Dimethylbenzimidazole by BluB: A Density Functional Theory Study」 J.Am. Chem. Soc. 2011, 133, 4079-4091.
9. Lintai Da, Junmin Quan*, YunDong Wu* 「Understanding the binding mode and function of BMS-488043 against HIV-1 viral entry」 Proteins: Struct., Funct., Bioinf. 2011, 79, 1810-1819. 10. Haixia Zou, Liyan Zhou, Yuanzhen Li, Hanbing Zhong, Zhengying Pan, Zhen Yang, Junmin Quan* 「Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype」 J. Med. Chem. 2010, 53, 994-1003.[1]