檢視杨娟娟的原始碼

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|<center>''' 杨娟娟  '''<br><img src="https://bio.fzu.edu.cn/__local/7/14/9D/FBAEC30D139AF8E62FC25C7F647_A9566C50_55352.png?e=.png  " width="180"></center><small>[https://bio.fzu.edu.cn/info/1012/2441.htm  福州大学生物科学与工程学院]

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'''杨娟娟'''，女，福州大学生物科学与工程学院教授。

==人物简历==

2019.06—至今     福州大学，生物科学与工程学院   副教授

2015.05—2019.05  福州大学，生物科学与工程学院   讲师

2011.09—2015.04  厦门大学，化学生物学专业理学   博士

2011.04—2011.09  中国科学院上海药物研究所交流学习

2008.09—2011.03  华东理工大学，制药工程与技术专业工学  硕士

2004.09—2008.07  郑州大学，制药工程专业工学      学士
==研究方向==
[[蛋白质化学]][[ 结构生物学]]

==科研项目==

1. 国家自然科学基金（青年基金），人源程序性死亡受体PD-1与其配体PD-L2负性调控免疫应答的结构基础研究，项目编号31700656，项目起止时间2018.01—2020.12，主持；

2. 福建省自然科学基金（青年基金），人程序性死亡配体PD-1与其配体PD-L2调节免疫应答的结构基础和功能研究，项目编号2017J05050，项目起止时间 2017.04-2020.04，主持；

3. 福州大学校人才项目，人源B7家族PD-1-PD-L2通路调节免疫应答的结构基础，项目起止时间2015.5—2017.5，主持。
==学术成果==
=== 论文 ===

1. Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-liang Ji, Donghai Lin*. Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis. Acta Biochim Biophys Sin, 2019, 51(2):139-149.

2. Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, Donghai Lin, Kejiang Lin*. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.Bioorganic Chemistry, 2019, 82: 58-67.

3. Yang Yang, Zhen Liu, Xiaoqin He, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai*, Wei Xu* and Lin Wei*. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. Journal of Biological Chemistry, 2019, 294(19): 7615-7631.

4. Taotao Chen, Zheng Chen, Huimin Wang, Xiaodong Chen, Juanjuan Yang, Aidong Han, Dong-Hai Lin, Jing Hong*. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective eﬀects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018, 40: 606-613.

5. Juanjuan Yang, Yindi Liu, Shuli Xu, Haiying Lin, Chun Meng, Donghai Lin*. Expression, puriﬁcation and characterization of the full-length SmpB protein from Mycobacterium tuberculosis. Protein expression and purification, 2018, 151: 9-17.

6. Juanjuan Yang, Lei Hu, Tiantian Cai, Qiuluan Chen, Qian Ma, Jie Yang, Chun Meng, Jing Hong*. Purification and identification of two novel antioxidant peptides from perilla (Perilla Frutescens L. Britton) seed protein hydrolysates. PLoS One, 2018, 13(7): 1-15.  

7. Lixian Mu, Lei Zhou, Juanjuan Yang, Li Zhuang, Jing Tang, Tong Liu, Jing Wu, Hailong Yang*. The first identified cathelicidin from tree frogs possesses anti‑inflammatory and partial LPS neutralization activities. Amino Acids, 2017, 49: 1571-1585.

8. Juanjuan Yang, Yindi Liu, Zhao Liu, Chun Meng, Donghai Lin*. Backbone and side-chain resonance assignments for the tmRNA binding protein, SmpB, from Mycobacterium tuberculosis. Biomolecular NMR Assignments, 2017, 11(2): 175-179.

9. Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Molecular Microbiology, 2015, 95(5), 791-803. 

10. Lin Wei, Chunjing Huang, Hailong Yang, Min Li, Juanjuan Yang, Xue Qiao, Lixian Mu, Fei Xiong, Jing Wu*, Wei Xu*. A potent anti-inflammatory peptide from the salivary glands of horsefly. Parasit Vectors, 2015, 8: 556-556.

11. Lin Wei§, Juanjuan Yang§, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan*, Donghai Lin*, Ren Lai*. Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial and Anti-inflammatory Peptide. J. Med.Chem. 2013, 56: 3546-3556(§, co-first author).

12.  Li Dong§, JuanJuan Yang§, Ying Wang, Huan Liu, LiXian Mu, Donghai Lin*, Ren Lai*. Structure-function  relationship  of  antimicrobial  peptide cathelicidin Pc-CATH1. Nat. Prod. Bioprospect., 2012, 2: 81–86 (§, co-first author).

13. Juanjuan Yang, Huicai Huang,  Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael–Michael Reaction. Synthesis, 2011, 12: 1984-1987. 

14. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye. As*, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde. Synthesis, 2011, 7:1085-1091.

15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective  Michael  Reaction  of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12: 5218-5221.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8: 3244-3250.

=== 专利申请 ===

1. 一种人源程序性死亡受体hPD-1单克隆抗体：杨娟娟，孟春，吕唯，刘照，吴茂，授权专利号 ZL 201611197005.3。

2. 一种人源程序性死亡因子配体hPD-L2单克隆抗体：杨娟娟，孟春，刘照，罗岭，夏菁潞，徐淑丽授权专利号：2017102780143。

==获奖情况==

1. 2018.11 福州大学生物科学与工程学院 青年教师“最佳一节课”教学竞赛三等奖

2. 2017.11 指导全国大学生生命科学竞赛 获得三等奖

3. 2017.06 福州大学优秀本科毕业论文指导老师<ref>[https://bio.fzu.edu.cn/index.htm 福州大学生物科学与工程学院]</ref>
==参考资料== 
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[[Category:教授]]